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Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism.
Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y, Ma Q, Chen P. Li D, et al. Among authors: chen p, chen b, chen y. Cell Host Microbe. 2024 Jan 10;32(1):48-62.e9. doi: 10.1016/j.chom.2023.11.006. Epub 2023 Dec 5. Cell Host Microbe. 2024. PMID: 38056458
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis.
Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P. Gu P, et al. Among authors: chen p, chen t, chen y. Cell Mol Immunol. 2023 Oct;20(10):1156-1170. doi: 10.1038/s41423-023-01070-5. Epub 2023 Aug 9. Cell Mol Immunol. 2023. PMID: 37553429 Free PMC article.
Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice.
Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Selva Nandakumar K, Jiang Y, Zhou H, Chen P. Li D, et al. Among authors: chen m, chen p. Acta Pharm Sin B. 2024 Jul;14(7):3068-3085. doi: 10.1016/j.apsb.2024.03.025. Epub 2024 Mar 22. Acta Pharm Sin B. 2024. PMID: 39027244 Free PMC article.
Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z, Jia W, Chen P. Li J, et al. Among authors: chen z, chen m, chen p, chen t, chen y. Mol Ther. 2023 Apr 5;31(4):1017-1032. doi: 10.1016/j.ymthe.2023.01.018. Epub 2023 Jan 24. Mol Ther. 2023. PMID: 36698311 Free PMC article.
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis.
Kuang J, Wang J, Li Y, Li M, Zhao M, Ge K, Zheng D, Cheung KCP, Liao B, Wang S, Chen T, Zhang Y, Wang C, Ji G, Chen P, Zhou H, Xie C, Zhao A, Jia W, Zheng X, Jia W. Kuang J, et al. Among authors: chen p, chen t. Cell Metab. 2023 Oct 3;35(10):1752-1766.e8. doi: 10.1016/j.cmet.2023.07.011. Epub 2023 Aug 16. Cell Metab. 2023. PMID: 37591244 Free article.
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z, Zhao X, Chen P, Gong S. Zeng Y, et al. Among authors: chen z, chen p, chen a, chen x. Cell Host Microbe. 2023 May 10;31(5):766-780.e7. doi: 10.1016/j.chom.2023.04.002. Epub 2023 Apr 25. Cell Host Microbe. 2023. PMID: 37100057 Free article.
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