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Page 1
The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding.
Singh SP, Smyth DJ, Cunningham KT, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wąsowska N, Sanders A, Jin R, White RF, Lilla S, Zanivan S, Schoenherr C, Inman GJ, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: smyth dj. EMBO Rep. 2024 Nov 28. doi: 10.1038/s44319-024-00323-2. Online ahead of print. EMBO Rep. 2024. PMID: 39609640 Free article.
The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells.
Singh SP, Smyth DJ, Cunningham K, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wosowska N, Sanders A, Jin R, Lilla S, Zanivan S, Schoenherr C, Inman G, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: smyth dj. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566701. doi: 10.1101/2023.11.13.566701. bioRxiv. 2023. PMID: 38014296 Free PMC article. Preprint.
Exogenous Transforming Growth Factor-β1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size.
Redgrave RE, Singh E, Tual-Chalot S, Park C, Hall D, Bennaceur K, Smyth DJ, Maizels RM, Spyridopoulos I, Arthur HM. Redgrave RE, et al. Among authors: smyth dj. Am J Pathol. 2024 Apr;194(4):562-573. doi: 10.1016/j.ajpath.2023.09.014. Epub 2023 Oct 11. Am J Pathol. 2024. PMID: 37832870 Free article.
Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.
Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V. Rekima A, et al. Among authors: smyth dj. Allergy. 2024 Aug;79(8):2247-2251. doi: 10.1111/all.16054. Epub 2024 Feb 13. Allergy. 2024. PMID: 38348877 No abstract available.
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.
Soskic B, Cano-Gamez E, Smyth DJ, Ambridge K, Ke Z, Matte JC, Bossini-Castillo L, Kaplanis J, Ramirez-Navarro L, Lorenc A, Nakic N, Esparza-Gordillo J, Rowan W, Wille D, Tough DF, Bronson PG, Trynka G. Soskic B, et al. Among authors: smyth dj. Nat Genet. 2022 Jun;54(6):817-826. doi: 10.1038/s41588-022-01066-3. Epub 2022 May 26. Nat Genet. 2022. PMID: 35618845 Free PMC article.
Immune disease variants modulate gene expression in regulatory CD4+ T cells.
Bossini-Castillo L, Glinos DA, Kunowska N, Golda G, Lamikanra AA, Spitzer M, Soskic B, Cano-Gamez E, Smyth DJ, Cattermole C, Alasoo K, Mann A, Kundu K, Lorenc A, Soranzo N, Dunham I, Roberts DJ, Trynka G. Bossini-Castillo L, et al. Among authors: smyth dj. Cell Genom. 2022 Apr 13;2(4):None. doi: 10.1016/j.xgen.2022.100117. Cell Genom. 2022. PMID: 35591976 Free PMC article.
128 results