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Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.
Funk AL, Katerji M, Afifi M, Nyswaner K, Woodroofe CC, Edwards ZC, Lindberg E, Bergman KL, Gough NR, Rubin MR, Karpińska K, Trotter EW, Dash S, Ries AL, James A, Robinson CM, Difilippantonio S, Karim BO, Chang TC, Chen L, Xu X, Doroshow JH, Ahel I, Marusiak AA, Swenson RE, Cappell SD, Brognard J. Funk AL, et al. Among authors: woodroofe cc. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.623840. doi: 10.1101/2024.11.19.623840. bioRxiv. 2024. PMID: 39605563 Free PMC article. Preprint.
Tools and tactics to define specificity of metabolic chemical reporters.
Mukherjee MM, Bond MR, Abramowitz LK, Biesbrock D, Woodroofe CC, Kim EJ, Swenson RE, Hanover JA. Mukherjee MM, et al. Among authors: woodroofe cc. Front Mol Biosci. 2023 Dec 7;10:1286690. doi: 10.3389/fmolb.2023.1286690. eCollection 2023. Front Mol Biosci. 2023. PMID: 38143802 Free PMC article.
Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate.
Ettedgui J, Blackman B, Raju N, Kotler SA, Chekmenev EY, Goodson BM, Merkle H, Woodroofe CC, LeClair CA, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: woodroofe cc. J Am Chem Soc. 2024 Jan 10;146(1):946-953. doi: 10.1021/jacs.3c11499. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38154120 Free PMC article.
Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer.
Khan I, Gril B, Paranjape AN, Robinson CM, Difilippantonio S, Biernat W, Bieńkowski M, Pęksa R, Duchnowska R, Jassem J, Brastianos PK, Metellus P, Bialecki E, Woodroofe CC, Wu H, Swenson RE, Steeg PS. Khan I, et al. Among authors: woodroofe cc. Mol Cancer Ther. 2023 May 4;22(5):646-658. doi: 10.1158/1535-7163.MCT-22-0815. Mol Cancer Ther. 2023. PMID: 36912773 Free PMC article.
Target engagement and drug residence time can be observed in living cells with BRET.
Robers MB, Dart ML, Woodroofe CC, Zimprich CA, Kirkland TA, Machleidt T, Kupcho KR, Levin S, Hartnett JR, Zimmerman K, Niles AL, Ohana RF, Daniels DL, Slater M, Wood MG, Cong M, Cheng YQ, Wood KV. Robers MB, et al. Among authors: woodroofe cc. Nat Commun. 2015 Dec 3;6:10091. doi: 10.1038/ncomms10091. Nat Commun. 2015. PMID: 26631872 Free PMC article.
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