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Multi-stage-mixing to create a core-then-shell structure improves DNA-loaded lipid nanoparticles' transfection by orders of magnitude.
Nong J, Gong X, Dang QM, Tiwari S, Patel M, Wu J, Hanna A, Park WJ, Atochina-Vasserman EN, Huang HT, Marcos-Contreras OA, Morris-Blanco KC, Miner JJ, Weissman D, Muzykantov VR, Gupta K, Issadore D, Myerson JW, Wang Z, Brenner JS. Nong J, et al. Among authors: patel m. bioRxiv [Preprint]. 2024 Nov 15:2024.11.12.623321. doi: 10.1101/2024.11.12.623321. bioRxiv. 2024. PMID: 39605450 Free PMC article. Preprint.
Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions.
Omo-Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Chase LS, Essien EO, Muzykantov V, Marcos-Contreras O, Myerson JW, Brenner JS. Omo-Lamai S, et al. bioRxiv [Preprint]. 2023 Jul 25:2023.07.21.550080. doi: 10.1101/2023.07.21.550080. bioRxiv. 2023. Update in: Adv Mater. 2024 Jun;36(26):e2312026. doi: 10.1002/adma.202312026 PMID: 37546837 Free PMC article. Updated. Preprint.
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Omo-Lamai S, Wang Y, Patel MN, Essien EO, Shen M, Majumdar A, Espy C, Wu J, Channer B, Tobin M, Murali S, Papp TE, Maheshwari R, Wang L, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Tsourkas A, Muzykantov V, Brodsky I, Shin S, Whitehead KA, Gaskill P, Discher D, Parhiz H, Brenner JS. Omo-Lamai S, et al. Among authors: patel mn. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589801. doi: 10.1101/2024.04.16.589801. bioRxiv. 2024. PMID: 38659905 Free PMC article. Preprint.
Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy.
Zaleski MH, Omo-Lamai S, Nong J, Chase LS, Myerson JW, Glassman PM, Lee F, Reyes-Esteves S, Wang Z, Patel MN, Peshkova AD, Komatsu H, Axelsen PH, Muzykantov VR, Marcos-Contreras OA, Brenner JS. Zaleski MH, et al. Among authors: patel mn. J Control Release. 2024 Oct;374:425-440. doi: 10.1016/j.jconrel.2024.07.070. Epub 2024 Aug 26. J Control Release. 2024. PMID: 39103056
Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System.
Zamora ME, Essien EO, Bhamidipati K, Murthy A, Liu J, Kim H, Patel MN, Nong J, Wang Z, Espy C, Chaudhry FN, Ferguson LT, Tiwari S, Hood ED, Marcos-Contreras OA, Omo-Lamai S, Shuvaeva T, Arguiri E, Wu J, Rauova L, Poncz M, Basil MC, Cantu E, Planer JD, Spiller K, Zepp J, Muzykantov VR, Myerson JW, Brenner JS. Zamora ME, et al. Among authors: patel mn. ACS Nano. 2024 Aug 20;18(33):22275-22297. doi: 10.1021/acsnano.4c06286. Epub 2024 Aug 6. ACS Nano. 2024. PMID: 39105696
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