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Cis-regulatory elements driving motor neuron-selective viral payload expression within the mammalian spinal cord.
Nagy MA, Price S, Wang K, Gill S, Ren E, Jayne L, Pajak V, Deighan S, Liu B, Lu X, Diallo A, Lo SC, Kleiman R, Henderson C, Suh J, Griffith EC, Greenberg ME, Hrvatin S. Nagy MA, et al. Among authors: kleiman r. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2418024121. doi: 10.1073/pnas.2418024121. Epub 2024 Nov 27. Proc Natl Acad Sci U S A. 2024. PMID: 39602276
16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons.
Buttermore ED, Anderson NC, Chen PF, Makhortova NR, Kim KH, Wafa SMA, Dwyer S, Micozzi JM, Winden KD, Zhang B, Han MJ, Kleiman RJ, Brownstein CA, Sahin M, Gonzalez-Heydrich J. Buttermore ED, et al. Among authors: kleiman rj. Front Psychiatry. 2022 Nov 3;13:924956. doi: 10.3389/fpsyt.2022.924956. eCollection 2022. Front Psychiatry. 2022. PMID: 36405918 Free PMC article.
An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety.
Chaudhary KW, Clancy CE, Yang PC, Pierson JB, Goldin AL, Koerner JE, Wisialowski TA, Valentin JP, Imredy JP, Lagrutta A, Authier S, Kleiman R, Sager PT, Hoffmann P, Pugsley MK. Chaudhary KW, et al. Among authors: kleiman r. Clin Transl Sci. 2024 Dec;17(12):e70098. doi: 10.1111/cts.70098. Clin Transl Sci. 2024. PMID: 39660576 Free PMC article. Review.
Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord.
Nagy MA, Price S, Wang K, Gill SP, Ren E, McElrath L, Pajak V, Deighan S, Liu B, Liu X, Diallo A, Lo SC, Kleiman R, Henderson C, Suh J, Griffith EC, Greenberg ME, Hrvatin S. Nagy MA, et al. Among authors: kleiman r. bioRxiv [Preprint]. 2024 Sep 3:2024.09.02.610875. doi: 10.1101/2024.09.02.610875. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2418024121. doi: 10.1073/pnas.2418024121 PMID: 39282347 Free PMC article. Updated. Preprint.
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
Wisialowski TA, Ether N, Foley CM, Kleiman R, Koshman Y, Leishman D, Martel E, Nichols JV, Popp J, Rajamani S, Riley S, Rossman EI, Vargas HM. Wisialowski TA, et al. Among authors: kleiman r. J Pharmacol Toxicol Methods. 2024 Jul-Aug;128:107515. doi: 10.1016/j.vascn.2024.107515. Epub 2024 May 20. J Pharmacol Toxicol Methods. 2024. PMID: 38777240 Free article. No abstract available.
Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial.
Nyang'wa BT, Berry C, Kazounis E, Motta I, Parpieva N, Tigay Z, Moodliar R, Dodd M, Solodovnikova V, Liverko I, Rajaram S, Rassool M, McHugh T, Spigelman M, Moore DA, Ritmeijer K, du Cros P, Fielding K; TB-PRACTECAL team. Nyang'wa BT, et al. Lancet Respir Med. 2024 Feb;12(2):117-128. doi: 10.1016/S2213-2600(23)00389-2. Epub 2023 Nov 16. Lancet Respir Med. 2024. PMID: 37980911 Free article. Clinical Trial.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
Rossman EI, Wisialowski TA, Vargas HM, Valentin JP, Rolf MG, Roche BM, Riley S, Pugsley MK, Nichols J, Li D, Leishman DJ, Kleiman RB, Greiter-Wilke A, Gintant GA, Engwall MJ, Delaunois A, Authier S. Rossman EI, et al. Among authors: kleiman rb. J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107270. doi: 10.1016/j.vascn.2023.107270. Epub 2023 May 8. J Pharmacol Toxicol Methods. 2023. PMID: 37164235
162 results