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Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research.
Dalvin LA, Andrews-Pfannkoch CM, Miley DR, Hogenson TL, Erickson SA, Malpotra S, Anderson KJ, Omer ME, Almada LL, Zhang C, Li H, Salomao DR, Shields CL, Lally SE, Malsch RM, Armitage JA, Holmes HL, Romero MF, Fautsch MP, Markovic SN, Fernandez-Zapico ME. Dalvin LA, et al. Among authors: almada ll. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):60. doi: 10.1167/iovs.65.13.60. Invest Ophthalmol Vis Sci. 2024. PMID: 39601636 Free PMC article.
Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers.
Hogenson TL, Xie H, Phillips WJ, Toruner MD, Li JJ, Horn IP, Kennedy DJ, Almada LL, Marks DL, Carr RM, Toruner M, Sigafoos AN, Koenig-Kappes AN, Olson RL, Tolosa EJ, Zhang C, Li H, Doles JD, Bleeker J, Barrett MT, Boyum JH, Kipp BR, Mahipal A, Hubbard JM, Scheffler Hanson TJ, Petersen GM, Dasari S, Oberg AL, Truty MJ, Graham RP, Levy MJ, Zhu M, Billadeau DD, Adjei AA, Dusetti N, Iovanna JL, Bekaii-Saab TS, Ma WW, Fernandez-Zapico ME. Hogenson TL, et al. Among authors: almada ll. JCI Insight. 2022 Nov 22;7(22):e158060. doi: 10.1172/jci.insight.158060. JCI Insight. 2022. PMID: 36256477 Free PMC article.
A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.
Horn IP, Marks DL, Koenig AN, Hogenson TL, Almada LL, Goldstein LE, Romecin Duran PA, Vera R, Vrabel AM, Cui G, Rabe KG, Bamlet WR, Mer G, Sicotte H, Zhang C, Li H, Petersen GM, Fernandez-Zapico ME. Horn IP, et al. Among authors: almada ll. J Biol Chem. 2021 Jan-Jun;296:100634. doi: 10.1016/j.jbc.2021.100634. Epub 2021 Apr 3. J Biol Chem. 2021. PMID: 33823155 Free PMC article.
KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. Sigafoos AN, et al. Among authors: almada ll. Cancer Res Commun. 2024 Jul 1;4(7):1677-1689. doi: 10.1158/2767-9764.CRC-23-0464. Cancer Res Commun. 2024. PMID: 38896052 Free PMC article.
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Pietrobono S, Anichini G, Sala C, Manetti F, Almada LL, Pepe S, Carr RM, Paradise BD, Sarkaria JN, Davila JI, Tofani L, Battisti I, Arrigoni G, Ying L, Zhang C, Li H, Meves A, Fernandez-Zapico ME, Stecca B. Pietrobono S, et al. Among authors: almada ll. Nat Commun. 2020 Nov 17;11(1):5865. doi: 10.1038/s41467-020-19575-2. Nat Commun. 2020. PMID: 33203881 Free PMC article.
Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME. Mills LD, et al. Among authors: almada ll. J Biol Chem. 2013 Apr 26;288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12. J Biol Chem. 2013. PMID: 23482563 Free PMC article.
52 results