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Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice.
Wang J, Iannarelli R, Pucciarelli S, Laudadio E, Galeazzi R, Giangrossi M, Falconi M, Cui L, Navia AM, Buccioni M, Marucci G, Tomassoni D, Serini L, Sut S, Maggi F, Dall'Acqua S, Marchini C, Amici A. Wang J, et al. Among authors: amici a. Pharmacol Res. 2020 Nov;161:105123. doi: 10.1016/j.phrs.2020.105123. Epub 2020 Aug 19. Pharmacol Res. 2020. PMID: 32822867
Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib.
Tilio M, Gambini V, Wang J, Garulli C, Kalogris C, Andreani C, Bartolacci C, Elexpuru Zabaleta M, Pietrella L, Hysi A, Iezzi M, Belletti B, Orlando F, Provinciali M, Galeazzi R, Marchini C, Amici A. Tilio M, et al. Among authors: amici a. Cancer Lett. 2016 Oct 10;381(1):76-84. doi: 10.1016/j.canlet.2016.07.028. Epub 2016 Jul 27. Cancer Lett. 2016. PMID: 27475932
Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.
Citron F, Segatto I, Vinciguerra GLR, Musco L, Russo F, Mungo G, D'Andrea S, Mattevi MC, Perin T, Schiappacassi M, Massarut S, Marchini C, Amici A, Vecchione A, Baldassarre G, Belletti B. Citron F, et al. Among authors: amici a. Cancer Res. 2020 Mar 1;80(5):1064-1077. doi: 10.1158/0008-5472.CAN-19-1793. Epub 2019 Dec 20. Cancer Res. 2020. PMID: 31862778
Evaluation of anticancer role of a novel ruthenium(II)-based compound compared with NAMI-A and cisplatin in impairing mitochondrial functionality and promoting oxidative stress in triple negative breast cancer models.
Silvestri S, Cirilli I, Marcheggiani F, Dludla P, Lupidi G, Pettinari R, Marchetti F, Di Nicola C, Falcioni G, Marchini C, Orlando P, Tiano L, Amici A. Silvestri S, et al. Among authors: amici a. Mitochondrion. 2021 Jan;56:25-34. doi: 10.1016/j.mito.2020.11.004. Epub 2020 Nov 19. Mitochondrion. 2021. PMID: 33220497
311 results