Yang DJ - Search Results

1

The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer.

Luo QY, Yang J, Di T, Xia ZF, Zhang L, Pan WT, Shi S, Yang LQ, Sun J, Qiu MZ, Yang DJ. Luo QY, et al. Among authors: yang dj. Acta Pharmacol Sin. 2024 Nov 26. doi: 10.1038/s41401-024-01414-5. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 39592733

2

Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma.

Yi H, Qiu MZ, Yuan L, Luo Q, Pan W, Zhou S, Zhang L, Yan X, Yang DJ. Yi H, et al. Among authors: yang dj. Cancer Med. 2020 Jun;9(12):4197-4206. doi: 10.1002/cam4.3090. Epub 2020 Apr 28. Cancer Med. 2020. PMID: 32346976 Free PMC article.

3

A multi-kinase inhibitor APG-2449 enhances the antitumor effect of ibrutinib in esophageal squamous cell carcinoma via EGFR/FAK pathway inhibition.

Luo QY, Zhou SN, Pan WT, Sun J, Yang LQ, Zhang L, Qiu MZ, Yang DJ. Luo QY, et al. Among authors: yang dj, yang lq. Biochem Pharmacol. 2021 Jan;183:114318. doi: 10.1016/j.bcp.2020.114318. Epub 2020 Nov 5. Biochem Pharmacol. 2021. PMID: 33159967

4

Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway.

Luo F, Lu FT, Qiu MZ, Zhou T, Ma WJ, Luo M, Zeng KM, Luo QY, Pan WT, Zhang L, Xia ZF, Zhang ZH, Cao JX, Zhao HY, Zhang L, Yang DJ. Luo F, et al. Among authors: yang dj. Cell Death Dis. 2021 Aug 5;12(8):772. doi: 10.1038/s41419-021-04042-7. Cell Death Dis. 2021. PMID: 34354046 Free PMC article.

5

APG-1252 combined with Cabozantinib inhibits hepatocellular carcinoma by suppressing MEK/ERK and CREB/Bcl-xl pathways.

Di T, Luo QY, Song JT, Yan XL, Zhang L, Pan WT, Guo Y, Lu FT, Sun YT, Xia ZF, Yang LQ, Qiu MZ, Yang DJ, Sun J. Di T, et al. Among authors: yang dj, yang lq. Int Immunopharmacol. 2024 Sep 30;139:112615. doi: 10.1016/j.intimp.2024.112615. Epub 2024 Jul 20. Int Immunopharmacol. 2024. PMID: 39032475

6

APG-1252-12A induces mitochondria-dependent apoptosis through inhibiting the antiapoptotic proteins Bcl-2/Bcl-xl in HL-60 cells.

Wang J, Yang D, Luo Q, Qiu M, Zhang L, Li B, Chen H, Yi H, Yan X, Li S, Sun J. Wang J, et al. Int J Oncol. 2017 Aug;51(2):563-572. doi: 10.3892/ijo.2017.4028. Epub 2017 Jun 6. Int J Oncol. 2017. PMID: 28586007

7

Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway.

Li BX, Wang HB, Qiu MZ, Luo QY, Yi HJ, Yan XL, Pan WT, Yuan LP, Zhang YX, Xu JH, Zhang L, Yang DJ. Li BX, et al. Among authors: yang dj. J Exp Clin Cancer Res. 2018 Mar 12;37(1):53. doi: 10.1186/s13046-018-0703-9. J Exp Clin Cancer Res. 2018. PMID: 29530056 Free PMC article.

8

A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity.

Pan W, Luo Q, Yan X, Yuan L, Yi H, Zhang L, Li B, Zhang Y, Sun J, Qiu MZ, Yang DJ. Pan W, et al. Among authors: yang dj. Biochem Pharmacol. 2018 Aug;154:127-135. doi: 10.1016/j.bcp.2018.04.020. Epub 2018 Apr 18. Biochem Pharmacol. 2018. PMID: 29679556

9

A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma.

Yi H, Yan X, Luo Q, Yuan L, Li B, Pan W, Zhang L, Chen H, Wang J, Zhang Y, Zhai Y, Qiu MZ, Yang DJ. Yi H, et al. Among authors: yang dj. J Exp Clin Cancer Res. 2018 May 2;37(1):97. doi: 10.1186/s13046-018-0765-8. J Exp Clin Cancer Res. 2018. PMID: 29716622 Free PMC article.

10

Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway.

Li BX, Wang HB, Qiu MZ, Luo QY, Yi HJ, Yan XL, Pan WT, Yuan LP, Zhang YX, Xu JH, Zhang L, Yang DJ. Li BX, et al. Among authors: yang dj. J Exp Clin Cancer Res. 2018 May 24;37(1):108. doi: 10.1186/s13046-018-0774-7. J Exp Clin Cancer Res. 2018. PMID: 29793514 Free PMC article.

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