Middleton L - Search Results

1

Longitudinal clinical and proteomic diabetes signatures in post-gestational diabetes women.

Chung HS, Middleton L, Garg M, Hristova VA, Vega RB, Baker DJ, Challis BG, Vitsios D, Hess S, Wallenius K, Holmäng A, Andersson-Hall U. Chung HS, et al. Among authors: middleton l. JCI Insight. 2024 Nov 26:e183213. doi: 10.1172/jci.insight.183213. Online ahead of print. JCI Insight. 2024. PMID: 39589852 Free article.

2

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses.

Middleton L, Harper AR, Nag A, Wang Q, Reznichenko A, Vitsios D, Petrovski S. Middleton L, et al. Nucleic Acids Res. 2022 May 6;50(8):4289-4301. doi: 10.1093/nar/gkac274. Nucleic Acids Res. 2022. PMID: 35474393 Free PMC article.

3

Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank.

Nag A, Dhindsa RS, Middleton L, Jiang X, Vitsios D, Wigmore E, Allman EL, Reznichenko A, Carss K, Smith KR, Wang Q, Challis B, Paul DS, Harper AR, Petrovski S. Nag A, et al. Among authors: middleton l. Am J Hum Genet. 2023 Mar 2;110(3):487-498. doi: 10.1016/j.ajhg.2023.02.002. Epub 2023 Feb 20. Am J Hum Genet. 2023. PMID: 36809768 Free PMC article.

4

Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank.

Garg M, Karpinski M, Matelska D, Middleton L, Burren OS, Hu F, Wheeler E, Smith KR, Fabre MA, Mitchell J, O'Neill A, Ashley EA, Harper AR, Wang Q, Dhindsa RS, Petrovski S, Vitsios D. Garg M, et al. Among authors: middleton l. Nat Genet. 2024 Sep;56(9):1821-1831. doi: 10.1038/s41588-024-01898-1. Epub 2024 Sep 11. Nat Genet. 2024. PMID: 39261665 Free PMC article.

5

Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning.

Vitsios D, Dhindsa RS, Middleton L, Gussow AB, Petrovski S. Vitsios D, et al. Among authors: middleton l. Nat Commun. 2021 Mar 8;12(1):1504. doi: 10.1038/s41467-021-21790-4. Nat Commun. 2021. PMID: 33686085 Free PMC article.

6

Author Correction: DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets.

Raies A, Tulodziecka E, Stainer J, Middleton L, Dhindsa RS, Hill P, Engkvist O, Harper AR, Petrovski S, Vitsios D. Raies A, et al. Among authors: middleton l. Commun Biol. 2023 Jul 11;6(1):710. doi: 10.1038/s42003-023-05086-5. Commun Biol. 2023. PMID: 37433831 Free PMC article. No abstract available.

7

DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets.

Raies A, Tulodziecka E, Stainer J, Middleton L, Dhindsa RS, Hill P, Engkvist O, Harper AR, Petrovski S, Vitsios D. Raies A, et al. Among authors: middleton l. Commun Biol. 2022 Nov 24;5(1):1291. doi: 10.1038/s42003-022-04245-4. Commun Biol. 2022. PMID: 36434048 Free PMC article.

8

Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data.

Middleton L, Melas I, Vasavda C, Raies A, Rozemberczki B, Dhindsa RS, Dhindsa JS, Weido B, Wang Q, Harper AR, Edwards G, Petrovski S, Vitsios D. Middleton L, et al. Sci Adv. 2024 May 10;10(19):eadj1424. doi: 10.1126/sciadv.adj1424. Epub 2024 May 8. Sci Adv. 2024. PMID: 38718126 Free PMC article.

9

Prospective and retrospective analysis of whole slide images of sentinel and targeted lymph node frozen sections in breast cancer.

Ye Q, Law T, Klippel D, Albarracin C, Chen H, Contreras A, Ding Q, Huo L, Khazai L, Middleton L, Resetkova E, Sahin A, Sun H, Sweeney K, Symmans W, Wu Y, Krishnamurthy S. Ye Q, et al. Among authors: middleton l. Mod Pathol. 2025 Jan 7:100708. doi: 10.1016/j.modpat.2025.100708. Online ahead of print. Mod Pathol. 2025. PMID: 39788205

10

Estimating relative risks and risk differences in randomised controlled trials: a systematic review of current practice.

Thompson J, Watson SI, Middleton L, Hemming K. Thompson J, et al. Among authors: middleton l. Trials. 2025 Jan 2;26(1):1. doi: 10.1186/s13063-024-08690-w. Trials. 2025. PMID: 39748241 Free PMC article. Review.

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