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Page 1
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.
Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M; Dominantly Inherited Alzheimer Network. Preische O, et al. Among authors: mcdade em. Nat Med. 2019 Feb;25(2):277-283. doi: 10.1038/s41591-018-0304-3. Epub 2019 Jan 21. Nat Med. 2019. PMID: 30664784 Free PMC article.
CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease.
Shen Y, Timsina J, Heo G, Beric A, Ali M, Wang C, Yang C, Wang Y, Western D, Liu M, Gorijala P, Budde J, Do A, Liu H, Gordon B, Llibre-Guerra JJ, Joseph-Mathurin N, Perrin RJ, Maschi D, Wyss-Coray T, Pastor P, Renton AE, Surace EI, Johnson ECB, Levey AI, Alvarez I, Levin J, Ringman JM, Allegri RF, Seyfried N, Day GS, Wu Q, Fernández MV, Tarawneh R, McDade E, Morris JC, Bateman RJ, Goate A; Dominantly Inherited Alzheimer Network; Ibanez L, Sung YJ, Cruchaga C. Shen Y, et al. Cell. 2024 Oct 31;187(22):6309-6326.e15. doi: 10.1016/j.cell.2024.08.049. Epub 2024 Sep 26. Cell. 2024. PMID: 39332414 Free PMC article.
Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease.
Li F, Eteleeb A, Buchser W, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Li F, et al. bioRxiv [Preprint]. 2021 Sep 1:2021.08.30.458295. doi: 10.1101/2021.08.30.458295. bioRxiv. 2021. Update in: Front Aging Neurosci. 2022 Sep 27;14:935279. doi: 10.3389/fnagi.2022.935279 PMID: 34494019 Free PMC article. Updated. Preprint.
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease.
Cash DM, Morgan KE, O'Connor A, Veale TD, Malone IB, Poole T, Benzinger TL, Gordon BA, Ibanez L, Li Y, Llibre-Guerra JJ, McDade E, Wang G, Chhatwal JP, Day GS, Huey E, Jucker M, Levin J, Niimi Y, Noble JM, Roh JH, Sánchez-Valle R, Schofield PR, Bateman RJ, Frost C, Fox NC; Dominantly Inherited Alzheimer Network (DIAN). Cash DM, et al. medRxiv [Preprint]. 2024 Nov 16:2024.11.12.24316919. doi: 10.1101/2024.11.12.24316919. medRxiv. 2024. PMID: 39606328 Free PMC article. Preprint.
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.
Millar PR, Gordon BA, Wisch JK, Schultz SA, Benzinger TL, Cruchaga C, Hassenstab JJ, Ibanez L, Karch C, Llibre-Guerra JJ, Morris JC, Perrin RJ, Supnet-Bell C, Xiong C, Allegri RF, Berman SB, Chhatwal JP, Chrem Mendez PA, Day GS, Hofmann A, Ikeuchi T, Jucker M, Lee JH, Levin J, Lopera F, Niimi Y, Sánchez-González VJ, Schofield PR, Sosa-Ortiz AL, Vöglein J; Dominantly Inherited Alzheimer Network; Bateman RJ, Ances BM, McDade EM. Millar PR, et al. Among authors: mcdade em. Mol Neurodegener. 2023 Dec 19;18(1):98. doi: 10.1186/s13024-023-00688-3. Mol Neurodegener. 2023. PMID: 38111006 Free PMC article.
Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.
Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, Levin J, McDade EM, Perrin RJ, Schofield PR, Xiong C, Morris JC, Bateman RJ, Jucker M, Benzinger TLS, Ances BM, Eggebrecht AT, Gordon BA; Dominantly Inherited Alzheimer Network. Wheelock MD, et al. Among authors: mcdade em. Brain. 2023 Jul 3;146(7):2928-2943. doi: 10.1093/brain/awac498. Brain. 2023. PMID: 36625756 Free PMC article.
Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan.
Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, Gordon B, Cruchaga C, Day GS, Levin J, Vöglein J, Ikeuchi T, Suzuki K, Allegri RF, Xiong C; Dominantly Inherited Alzheimer Network (DIAN). Luo J, et al. Among authors: mcdade em. Brain. 2022 Dec 19;145(12):4459-4473. doi: 10.1093/brain/awac238. Brain. 2022. PMID: 35925685 Free PMC article.
Alzheimer Disease.
McDade EM. McDade EM. Continuum (Minneap Minn). 2022 Jun 1;28(3):648-675. doi: 10.1212/CON.0000000000001131. Continuum (Minneap Minn). 2022. PMID: 35678397 Review.
CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease.
Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, Chhatwal JP, Graff-Radford NR, Mori H, Levin J, Noble JM, Allegri R, Schofield PR, Marcus DS, Holtzman DM, Morris JC, Benzinger TLS, McDade EM, Bateman RJ, Ances BM. Strain JF, et al. Among authors: mcdade em. Neurobiol Dis. 2022 Jun 15;168:105714. doi: 10.1016/j.nbd.2022.105714. Epub 2022 Mar 28. Neurobiol Dis. 2022. PMID: 35358703 Free PMC article.
33 results