Germann AL - Search Results

1

Null method to estimate the maximal PA at subsaturating concentrations of agonist.

Germann AL, Pierce SR, Steinbach JH, Akk G. Germann AL, et al. J Gen Physiol. 2025 Jan 6;157(1):e202413644. doi: 10.1085/jgp.202413644. Epub 2024 Nov 25. J Gen Physiol. 2025. PMID: 39585302

2

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor.

Pierce SR, Germann AL, Covey DF, Evers AS, Steinbach JH, Akk G. Pierce SR, et al. Among authors: germann al. Mol Pharmacol. 2024 Oct 17;106(5):264-277. doi: 10.1124/molpharm.124.000960. Mol Pharmacol. 2024. PMID: 39214710

3

Direct measurements of neurosteroid binding to specific sites on GABA_A receptors.

Chintala SM, Tateiwa H, Qian M, Xu Y, Amtashar F, Chen ZW, Kirkpatrick CC, Bracamontes J, Germann AL, Akk G, Covey DF, Evers AS. Chintala SM, et al. Among authors: germann al. Br J Pharmacol. 2024 Nov;181(21):4229-4244. doi: 10.1111/bph.16490. Epub 2024 Jul 8. Br J Pharmacol. 2024. PMID: 38978389 Free PMC article.

4

Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay.

Germann AL, Xu Y, Covey DF, Evers AS, Akk G. Germann AL, et al. ACS Chem Neurosci. 2024 Mar 6;15(5):909-915. doi: 10.1021/acschemneuro.3c00836. Epub 2024 Feb 22. ACS Chem Neurosci. 2024. PMID: 38386612

5

UNC-49 is a redox-sensitive GABA_A receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.

Pohl F, Germann AL, Mao J, Hou S, Bakare B, Kong Thoo Lin P, Yates K, Nonet ML, Akk G, Kornfeld K, Held JM. Pohl F, et al. Among authors: germann al. Sci Adv. 2023 Nov 3;9(44):eadh2584. doi: 10.1126/sciadv.adh2584. Epub 2023 Nov 1. Sci Adv. 2023. PMID: 37910615 Free PMC article.

6

Potentiation of the GABA_AR reveals variable energetic contributions by etiocholanolone and propofol.

Pierce SR, Xu SQ, Germann AL, Steinbach JH, Akk G. Pierce SR, et al. Among authors: germann al. Biophys J. 2024 Jul 16;123(14):1954-1967. doi: 10.1016/j.bpj.2023.09.014. Epub 2023 Sep 26. Biophys J. 2024. PMID: 37752702

7

Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABA_A Receptor.

Arias HR, Pierce SR, Germann AL, Xu SQ, Ortells MO, Sakamoto S, Manetti D, Romanelli MN, Hamachi I, Akk G. Arias HR, et al. Among authors: germann al. Mol Pharmacol. 2023 Sep;104(3):115-131. doi: 10.1124/molpharm.123.000692. Epub 2023 Jun 14. Mol Pharmacol. 2023. PMID: 37316350 Free PMC article.

8

Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA_A Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor.

Pierce SR, Germann AL, Xu SQ, Menon SL, Ortells MO, Arias HR, Akk G. Pierce SR, et al. Among authors: germann al. Biomolecules. 2023 Apr 20;13(4):698. doi: 10.3390/biom13040698. Biomolecules. 2023. PMID: 37189445 Free PMC article.

9

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors.

Tateiwa H, Chintala SM, Chen Z, Wang L, Amtashar F, Bracamontes J, Germann AL, Pierce SR, Covey DF, Akk G, Evers AS. Tateiwa H, et al. Among authors: germann al. Biomolecules. 2023 Feb 9;13(2):341. doi: 10.3390/biom13020341. Biomolecules. 2023. PMID: 36830708 Free PMC article.

10

Modulation of the mammalian GABA_A receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

Arias HR, Germann AL, Pierce SR, Sakamoto S, Ortells MO, Hamachi I, Akk G. Arias HR, et al. Among authors: germann al. Br J Pharmacol. 2022 Dec;179(24):5323-5337. doi: 10.1111/bph.15948. Epub 2022 Sep 27. Br J Pharmacol. 2022. PMID: 36082615 Free PMC article.

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