Akk G - Search Results

1

Null method to estimate the maximal PA at subsaturating concentrations of agonist.

Germann AL, Pierce SR, Steinbach JH, Akk G. Germann AL, et al. Among authors: akk g. J Gen Physiol. 2025 Jan 6;157(1):e202413644. doi: 10.1085/jgp.202413644. Epub 2024 Nov 25. J Gen Physiol. 2025. PMID: 39585302

2

Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids.

Akkerman V, Reinholdt P, Schnoor-Madsen R, Lauritsen L, Bader J, Qian M, Xu Y, Akk G, Scheidt HA, Müller P, Covey DF, Evers AS, Kongsted J, Wüstner D. Akkerman V, et al. Among authors: akk g. ACS Chem Neurosci. 2024 Dec 4;15(23):4322-4336. doi: 10.1021/acschemneuro.4c00571. Epub 2024 Nov 22. ACS Chem Neurosci. 2024. PMID: 39574303

3

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Sep 16;14(1):21579. doi: 10.1038/s41598-024-70321-w. Sci Rep. 2024. PMID: 39284864 Free PMC article. No abstract available.

4

Three classes of propofol binding sites on GABA_A receptors.

Chen ZW, Chintala SM, Bracamontes J, Sugasawa Y, Pierce SR, Varga BR, Smith EH, Edge CJ, Franks NP, Cheng WWL, Akk G, Evers AS. Chen ZW, et al. Among authors: akk g. J Biol Chem. 2024 Oct;300(10):107778. doi: 10.1016/j.jbc.2024.107778. Epub 2024 Sep 11. J Biol Chem. 2024. PMID: 39270821 Free PMC article.

5

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor.

Pierce SR, Germann AL, Covey DF, Evers AS, Steinbach JH, Akk G. Pierce SR, et al. Among authors: akk g. Mol Pharmacol. 2024 Oct 17;106(5):264-277. doi: 10.1124/molpharm.124.000960. Mol Pharmacol. 2024. PMID: 39214710

6

Direct measurements of neurosteroid binding to specific sites on GABA_A receptors.

Chintala SM, Tateiwa H, Qian M, Xu Y, Amtashar F, Chen ZW, Kirkpatrick CC, Bracamontes J, Germann AL, Akk G, Covey DF, Evers AS. Chintala SM, et al. Among authors: akk g. Br J Pharmacol. 2024 Nov;181(21):4229-4244. doi: 10.1111/bph.16490. Epub 2024 Jul 8. Br J Pharmacol. 2024. PMID: 38978389 Free PMC article.

7

Tabernanthalog and ibogainalog inhibit the α7 and α9α10 nicotinic acetylcholine receptors via different mechanisms and with higher potency than the GABA_A receptor and Ca_V2.2 channel.

Tae HS, Ortells MO, Yousuf A, Xu SQ, Akk G, Adams DJ, Arias HR. Tae HS, et al. Among authors: akk g. Biochem Pharmacol. 2024 May;223:116183. doi: 10.1016/j.bcp.2024.116183. Epub 2024 Apr 3. Biochem Pharmacol. 2024. PMID: 38580167 Free article.

8

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

9

Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay.

Germann AL, Xu Y, Covey DF, Evers AS, Akk G. Germann AL, et al. Among authors: akk g. ACS Chem Neurosci. 2024 Mar 6;15(5):909-915. doi: 10.1021/acschemneuro.3c00836. Epub 2024 Feb 22. ACS Chem Neurosci. 2024. PMID: 38386612

10

UNC-49 is a redox-sensitive GABA_A receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.

Pohl F, Germann AL, Mao J, Hou S, Bakare B, Kong Thoo Lin P, Yates K, Nonet ML, Akk G, Kornfeld K, Held JM. Pohl F, et al. Among authors: akk g. Sci Adv. 2023 Nov 3;9(44):eadh2584. doi: 10.1126/sciadv.adh2584. Epub 2023 Nov 1. Sci Adv. 2023. PMID: 37910615 Free PMC article.

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