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Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Krotee P, et al. J Biol Chem. 2018 Feb 23;293(8):2888-2902. doi: 10.1074/jbc.M117.806109. Epub 2017 Dec 27. J Biol Chem. 2018. PMID: 29282295 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 39750886
Three-repeat and four-repeat tau isoforms form different oligomers.
Shahpasand-Kroner H, Portillo J, Lantz C, Seidler PM, Sarafian N, Loo JA, Bitan G. Shahpasand-Kroner H, et al. Among authors: seidler pm. Protein Sci. 2022 Mar;31(3):613-627. doi: 10.1002/pro.4257. Epub 2022 Jan 7. Protein Sci. 2022. PMID: 34902187 Free PMC article.
De novo designed protein inhibitors of amyloid aggregation and seeding.
Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. Murray KA, et al. Among authors: seidler pm. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206240119. doi: 10.1073/pnas.2206240119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969734 Free PMC article.
Structure-based inhibitors of tau aggregation.
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. Seidler PM, et al. Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20. Nat Chem. 2018. PMID: 29359764 Free PMC article.
29 results