Henry SP - Search Results

1

Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.

Kim TW, Papagiannis CN, Zwick LS, Snyder P, Engelhardt JA, Yu RZ, Hoffmaster CM, Rastogi A, Henry SP. Kim TW, et al. Among authors: henry sp. Regul Toxicol Pharmacol. 2025 Jan;155:105743. doi: 10.1016/j.yrtph.2024.105743. Epub 2024 Nov 22. Regul Toxicol Pharmacol. 2025. PMID: 39580013 Free article.

2

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice.

Kim TW, Papagiannis CN, Zwick LS, Engelhardt JA, Hoffmaster CM, Post NM, Matson JE, Hsiao JA, Burel SA, Henry SP. Kim TW, et al. Among authors: henry sp. Toxicol Pathol. 2019 Jan;47(1):82-92. doi: 10.1177/0192623318813143. Epub 2018 Dec 25. Toxicol Pathol. 2019. PMID: 30585133

3

Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice.

Zanardi TA, Kim TW, Shen L, Serota D, Papagiannis C, Park SY, Kim Y, Henry SP. Zanardi TA, et al. Among authors: henry sp. Nucleic Acid Ther. 2018 Aug;28(4):233-241. doi: 10.1089/nat.2017.0706. Epub 2018 Apr 30. Nucleic Acid Ther. 2018. PMID: 29708844

4

Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc₃-Conjugated Antisense Oligonucleotides.

Wang Y, Yu RZ, Henry S, Geary RS. Wang Y, et al. Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):475-485. doi: 10.1080/17425255.2019.1621838. Epub 2019 May 30. Expert Opin Drug Metab Toxicol. 2019. PMID: 31144994 Review.

5

Impurity Qualification Toxicology Study for a 2'-O-Methoxyethyl-Modified Antisense Inhibitor in Mice.

Kim TW, Papagiannis C, Capaldi D, McPherson AK, Mahdi F, Luu N, Rodriguez AA, Hoffmaster C, Serota D, Henry SP. Kim TW, et al. Among authors: henry sp. Nucleic Acid Ther. 2020 Feb;30(1):14-21. doi: 10.1089/nat.2019.0780. Epub 2019 Nov 5. Nucleic Acid Ther. 2020. PMID: 31687889

6

Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.

Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Yu RZ, et al. Among authors: henry sp. Nucleic Acid Ther. 2020 Oct;30(5):265-275. doi: 10.1089/nat.2020.0867. Epub 2020 Aug 19. Nucleic Acid Ther. 2020. PMID: 32833564 Clinical Trial.

7

Assessment of the Effect of Organ Impairment on the Pharmacokinetics of 2'-MOE and Phosphorothioate Modified Antisense Oligonucleotides.

Wang Y, Diep JK, Yu RZ, Hurh E, Karwatowska-Prokopczuk E, Schneider E, Henry S, Bhanot S, Geary RS. Wang Y, et al. J Clin Pharmacol. 2023 Jan;63(1):21-28. doi: 10.1002/jcph.2121. Epub 2022 Jul 26. J Clin Pharmacol. 2023. PMID: 35801818 Review.

8

A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.

Jeong JS, Rastogi A, Kim TW, Henry S, Hoffmaster CM, Kim SY, Kim W, Lee SY, Park JD, Wi IS, Yu WJ, Lee J. Jeong JS, et al. Nucleic Acid Ther. 2024 Dec;34(6):285-294. doi: 10.1089/nat.2024.0057. Epub 2024 Nov 25. Nucleic Acid Ther. 2024. PMID: 39585752

9

Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626, a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2.

Zanardi TA, Han SC, Jeong EJ, Rime S, Yu RZ, Chakravarty K, Henry SP. Zanardi TA, et al. Among authors: henry sp. J Pharmacol Exp Ther. 2012 Nov;343(2):489-96. doi: 10.1124/jpet.112.197426. Epub 2012 Aug 22. J Pharmacol Exp Ther. 2012. PMID: 22915769

10

Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies.

Kim TW, Kim KS, Seo JW, Park SY, Henry SP. Kim TW, et al. Among authors: henry sp. J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):49-60. doi: 10.1016/j.vascn.2013.10.005. Epub 2013 Nov 8. J Pharmacol Toxicol Methods. 2014. PMID: 24211663 Free article.

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