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Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation.
Hsiehchen D, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H. Hsiehchen D, et al. Among authors: antonarakis es. Cancer Cell. 2024 Dec 9;42(12):1985-1987. doi: 10.1016/j.ccell.2024.10.017. Epub 2024 Nov 21. Cancer Cell. 2024. PMID: 39577419
Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers.
Muquith M, Espinoza M, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H, Hsiehchen D. Muquith M, et al. Among authors: antonarakis es. Nat Cancer. 2024 Jul;5(7):1121-1129. doi: 10.1038/s43018-024-00752-x. Epub 2024 Mar 25. Nat Cancer. 2024. PMID: 38528112
Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes.
Bergom HE, Boytim E, McSweeney S, Sadeghipour N, Elliott A, Passow R, Toye E, Li X, Likasitwatanakul P, Geynisman DM, Dehm SM, Halabi S, Sharifi N, Antonarakis ES, Ryan CJ, Hwang J. Bergom HE, et al. Among authors: antonarakis es. JCI Insight. 2024 Oct 22;9(20):e183158. doi: 10.1172/jci.insight.183158. JCI Insight. 2024. PMID: 39207857 Free PMC article.
Driver mutations associated with signatures of platinum sensitivity in germ cell tumors.
Sawa YC, Jia L, Krause H, Meagher M, Millard F, Elliott A, Lafin JT, Jamieson C, Antonarakis ES, D'Souza A, Giannikou K, Amatruda JF, Daneshmand S, McKay RR, Oberley M, Nabhan C, Bagrodia A. Sawa YC, et al. Among authors: antonarakis es. NPJ Precis Oncol. 2024 Nov 2;8(1):249. doi: 10.1038/s41698-024-00727-2. NPJ Precis Oncol. 2024. PMID: 39488665 Free PMC article.
Isolation of Plasma Extracellular Vesicles for High-Depth Analysis of Proteomic Biomarkers in Metastatic Castration-Resistant Prostate Cancer Patients.
Arafa AT, Ludwig M, Tuncer O, Kollitz L, Gustafson A, Boytim E, Luo C, Sabal B, Steinberger D, Zhao Y, Dehm SM, Cayci Z, Hwang J, Villalta PW, Antonarakis ES, Drake JM. Arafa AT, et al. Among authors: antonarakis es. Cancers (Basel). 2024 Dec 21;16(24):4261. doi: 10.3390/cancers16244261. Cancers (Basel). 2024. PMID: 39766159 Free PMC article.
Pan-cancer genomic analysis reveals FOXA1 amplification is associated with adverse outcomes in non-small cell lung, prostate, and breast cancers.
Goglia AG, Alshalalfa M, Khan A, Isakov DR, Hougen HY, Swami N, Kannikal J, Mcbride SM, Gomez DR, Punnen S, Nguyen PL, Iyengar P, Antonarakis ES, Mahal BA, Dee EC. Goglia AG, et al. Among authors: antonarakis es. J Natl Cancer Inst. 2025 Jan 1;117(1):188-197. doi: 10.1093/jnci/djae224. J Natl Cancer Inst. 2025. PMID: 39254651
432 results