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Latent-TGF-β has a domain swapped architecture.
Nishimura S, Jin M, Seed R, Shing T, Cheng Y. Nishimura S, et al. Res Sq [Preprint]. 2024 Nov 1:rs.3.rs-5154292. doi: 10.21203/rs.3.rs-5154292/v1. Res Sq. 2024. PMID: 39574885 Free PMC article. Preprint.
Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Takasaka N, et al. Among authors: nishimura sl. JCI Insight. 2018 Oct 18;3(20):e122591. doi: 10.1172/jci.insight.122591. JCI Insight. 2018. PMID: 30333313 Free PMC article.
Dynamic allostery drives autocrine and paracrine TGF-β signaling.
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. Jin M, et al. Among authors: nishimura sl. Cell. 2024 Oct 31;187(22):6200-6219.e23. doi: 10.1016/j.cell.2024.08.036. Epub 2024 Sep 16. Cell. 2024. PMID: 39288764 Free PMC article.
Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Minagawa S, et al. Among authors: nishimura sl. Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074. Sci Transl Med. 2014. PMID: 24944194 Free PMC article.
A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. Seed RI, et al. Among authors: nishimura sl. Sci Immunol. 2021 Mar 26;6(57):eabf0558. doi: 10.1126/sciimmunol.abf0558. Sci Immunol. 2021. PMID: 33771888 Free PMC article.
3,101 results