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Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma.
Fernandez EG, Mai WX, Song K, Bayley NA, Kim J, Zhu H, Pioso M, Young P, Andrasz CL, Cadet D, Liau LM, Li G, Yong WH, Rodriguez FJ, Dixon SJ, Souers AJ, Li JJ, Graeber TG, Cloughesy TF, Nathanson DA. Fernandez EG, et al. Among authors: nathanson da. Nat Commun. 2024 Nov 21;15(1):10089. doi: 10.1038/s41467-024-54138-9. Nat Commun. 2024. PMID: 39572533 Free PMC article.
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. Mai WX, et al. Among authors: nathanson da. Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9. Nat Med. 2017. PMID: 29035366 Free PMC article.
Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation.
Davidson TB, Lee A, Hsu M, Sedighim S, Orpilla J, Treger J, Mastall M, Roesch S, Rapp C, Galvez M, Mochizuki A, Antonios J, Garcia A, Kotecha N, Bayless N, Nathanson D, Wang A, Everson R, Yong WH, Cloughesy TF, Liau LM, Herold-Mende C, Prins RM. Davidson TB, et al. Clin Cancer Res. 2019 Mar 15;25(6):1913-1922. doi: 10.1158/1078-0432.CCR-18-1176. Epub 2018 Nov 29. Clin Cancer Res. 2019. PMID: 30498094 Free PMC article.
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma.
Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. Lee AH, et al. Among authors: nathanson da. Nat Commun. 2021 Nov 26;12(1):6938. doi: 10.1038/s41467-021-26940-2. Nat Commun. 2021. PMID: 34836966 Free PMC article.
CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis.
Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. Minami JK, et al. Among authors: nathanson da. Cancer Cell. 2023 Jun 12;41(6):1048-1060.e9. doi: 10.1016/j.ccell.2023.05.001. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236196 Free PMC article.
D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation.
Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. Pianka ST, et al. Among authors: nathanson da. Cancer Res Commun. 2024 Mar 22;4(3):876-894. doi: 10.1158/2767-9764.CRC-23-0271. Cancer Res Commun. 2024. PMID: 38445960 Free PMC article.
Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry.
Chakhoyan A, Yao J, Leu K, Pope WB, Salamon N, Yong W, Lai A, Nghiemphu PL, Everson RG, Prins RM, Liau LM, Nathanson DA, Cloughesy TF, Ellingson BM. Chakhoyan A, et al. Among authors: nathanson da. Sci Rep. 2019 Feb 26;9(1):2846. doi: 10.1038/s41598-018-37564-w. Sci Rep. 2019. PMID: 30808879 Free PMC article.
71 results