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Towards the design of ligands of the internal pocket TEADs C-terminal domain.
Toulotte F, Coevoet M, Liberelle M, Bailly F, Zagiel B, Gelin M, Allemand F, Fourquet P, Melnyk P, Guichou JF, Cotelle P. Toulotte F, et al. Among authors: coevoet m. Eur J Med Chem. 2025 Jan 15;282:117026. doi: 10.1016/j.ejmech.2024.117026. Epub 2024 Nov 12. Eur J Med Chem. 2025. PMID: 39571457
High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists.
Bolteau R, Duroux R, Laversin A, Vreulz B, Shiriaeva A, Stauch B, Han GW, Cherezov V, Renault N, Barczyk A, Ravez S, Coevoet M, Melnyk P, Liberelle M, Yous S. Bolteau R, et al. Among authors: coevoet m. Eur J Med Chem. 2022 Nov 5;241:114620. doi: 10.1016/j.ejmech.2022.114620. Epub 2022 Jul 22. Eur J Med Chem. 2022. PMID: 35933788
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P. Sergeant N, et al. Among authors: coevoet m. Neurobiol Dis. 2019 Sep;129:217-233. doi: 10.1016/j.nbd.2019.03.028. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928644
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanché PE, Buée L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P. Gay M, et al. Among authors: coevoet m. Eur J Med Chem. 2018 Nov 5;159:104-125. doi: 10.1016/j.ejmech.2018.08.092. Epub 2018 Sep 22. Eur J Med Chem. 2018. PMID: 30268822
14 results