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Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. Kwon JJ, et al. Among authors: dharmaiah s. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.618529. doi: 10.1101/2024.10.22.618529. bioRxiv. 2024. PMID: 39484452 Free PMC article. Preprint.
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. Whitley MJ, et al. Among authors: dharmaiah s. Sci Adv. 2024 Feb 16;10(7):eadj4137. doi: 10.1126/sciadv.adj4137. Epub 2024 Feb 14. Sci Adv. 2024. PMID: 38354232 Free PMC article.
Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Hariharan S, Whitfield BT, Pirozzi CJ, Waitkus MS, Brown MC, Bowie ML, Irvin DM, Roso K, Fuller R, Hostettler J, Dharmaiah S, Gibson EA, Briley A, Mangoli A, Fraley C, Shobande M, Stevenson K, Zhang G, Malgulwar PB, Roberts H, Roskoski M, Spasojevic I, Keir ST, He Y, Castro MG, Huse JT, Ashley DM. Hariharan S, et al. Among authors: dharmaiah s. Nat Commun. 2024 Jan 25;15(1):730. doi: 10.1038/s41467-024-44932-w. Nat Commun. 2024. PMID: 38272925 Free PMC article.
Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Hariharan S, Whitfield BT, Pirozzi CJ, Waitkus MS, Brown MC, Bowie ML, Irvin DM, Roso K, Fuller R, Hostettler J, Dharmaiah S, Gibson EA, Briley A, Mangoli A, Fraley C, Shobande M, Stevenson K, Zhang G, Malgulwar PB, Roberts H, Roskoski M, Spasojevic I, Keir ST, He Y, Castro MG, Huse JT, Ashley DM. Hariharan S, et al. Among authors: dharmaiah s. bioRxiv [Preprint]. 2023 Apr 21:2023.04.20.537594. doi: 10.1101/2023.04.20.537594. bioRxiv. 2023. Update in: Nat Commun. 2024 Jan 25;15(1):730. doi: 10.1038/s41467-024-44932-w PMID: 37131619 Free PMC article. Updated. Preprint.
Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.
Malgulwar PB, Danussi C, Dharmaiah S, Johnson WE, Rao A, Huse JT. Malgulwar PB, et al. Among authors: dharmaiah s. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.523324. doi: 10.1101/2023.01.09.523324. bioRxiv. 2023. Update in: Neuro Oncol. 2024 Jan 5;26(1):55-67. doi: 10.1093/neuonc/noad155 PMID: 36711727 Free PMC article. Updated. Preprint.
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