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Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.
Bissegger L, Constantin TA, Keles E, Raguž L, Barlow-Busch I, Orbegozo C, Schaefer T, Borlandelli V, Bohnacker T, Sriramaratnam R, Schäfer A, Gstaiger M, Burke JE, Borsari C, Wymann MP. Bissegger L, et al. Among authors: schaefer t. Chem Sci. 2024 Nov 12;15(48):20274-20291. doi: 10.1039/d4sc05459h. eCollection 2024 Dec 11. Chem Sci. 2024. PMID: 39568927 Free PMC article.
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP. Borsari C, et al. Among authors: schaefer a, schaefer t. J Am Chem Soc. 2022 Apr 13;144(14):6326-6342. doi: 10.1021/jacs.1c13568. Epub 2022 Mar 30. J Am Chem Soc. 2022. PMID: 35353516 Free PMC article.
Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M, Bissegger L, Tarantelli C, Beaufils F, Prescimone A, Mohamed Seid Hedad H, Kayali O, Orbegozo C, Raguž L, Schaefer T, Hebeisen P, Bertoni F, Wymann MP, Borsari C. De Pascale M, et al. Among authors: schaefer t. Eur J Med Chem. 2023 Feb 15;248:115038. doi: 10.1016/j.ejmech.2022.115038. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36634458 Free article.
Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate.
Schaefer T, Mittal N, Wang H, Ataman M, Candido S, Lötscher J, Velychko S, Tintignac L, Bock T, Börsch A, Baßler J, Rao TN, Zmajkovic J, Roffeis S, Löliger J, Jacob F, Dumlin A, Schürch C, Schmidt A, Skoda RC, Wymann MP, Hess C, Schöler HR, Zaehres H, Hurt E, Zavolan M, Lengerke C. Schaefer T, et al. Cell Rep. 2024 Oct 22;43(10):114807. doi: 10.1016/j.celrep.2024.114807. Epub 2024 Oct 3. Cell Rep. 2024. PMID: 39368083 Free article.
AKT-driven phospho-patterns of pluripotency.
Schaefer T, Lengerke C. Schaefer T, et al. Cell Cycle. 2015;14(24):3784-5. doi: 10.1080/15384101.2015.1115642. Cell Cycle. 2015. PMID: 26697835 Free PMC article. No abstract available.
327 results