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Page 1
Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.
Bissegger L, Constantin TA, Keles E, Raguž L, Barlow-Busch I, Orbegozo C, Schaefer T, Borlandelli V, Bohnacker T, Sriramaratnam R, Schäfer A, Gstaiger M, Burke JE, Borsari C, Wymann MP. Bissegger L, et al. Among authors: raguz l. Chem Sci. 2024 Nov 12;15(48):20274-20291. doi: 10.1039/d4sc05459h. eCollection 2024 Dec 11. Chem Sci. 2024. PMID: 39568927 Free PMC article.
Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M, Bissegger L, Tarantelli C, Beaufils F, Prescimone A, Mohamed Seid Hedad H, Kayali O, Orbegozo C, Raguž L, Schaefer T, Hebeisen P, Bertoni F, Wymann MP, Borsari C. De Pascale M, et al. Among authors: raguz l. Eur J Med Chem. 2023 Feb 15;248:115038. doi: 10.1016/j.ejmech.2022.115038. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36634458 Free article.
Biosynthesis of the Sphingolipid Inhibitors Sphingofungins in Filamentous Fungi Requires Aminomalonate as a Metabolic Precursor.
Bissell AU, Rautschek J, Hoefgen S, Raguž L, Mattern DJ, Saeed N, Janevska S, Jojić K, Huang Y, Kufs JE, Herboeck B, Guo H, Hillmann F, Beemelmanns C, Valiante V. Bissell AU, et al. Among authors: raguz l. ACS Chem Biol. 2022 Feb 18;17(2):386-394. doi: 10.1021/acschembio.1c00839. Epub 2022 Jan 13. ACS Chem Biol. 2022. PMID: 35023724
Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action.
Brand M, Wang L, Agnello S, Gazzola S, Gall FM, Raguž L, Kaiser M, Schmidt RS, Ritschl A, Jelk J, Hemphill A, Mäser P, Bütikofer P, Adams M, Riedl R. Brand M, et al. Among authors: raguz l. Angew Chem Int Ed Engl. 2021 Jul 5;60(28):15613-15621. doi: 10.1002/anie.202102153. Epub 2021 May 10. Angew Chem Int Ed Engl. 2021. PMID: 33730410 Free PMC article.
Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives.
Roman D, Raguž L, Keiff F, Meyer F, Barthels F, Schirmeister T, Kloss F, Beemelmanns C. Roman D, et al. Among authors: raguz l. Org Lett. 2020 May 15;22(10):3744-3748. doi: 10.1021/acs.orglett.0c00723. Epub 2020 Mar 26. Org Lett. 2020. PMID: 32212714
14 results