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Page 1
Salcaprozate-based ionic liquids for GLP-1 gastric delivery: A mechanistic understanding of in vivo performance.
Rebollo R, Niu Z, Blaabjerg L, La Zara D, Juel T, Pedersen HD, Andersson V, Benova M, Krogh C, Pons R, Holm TP, Wahlund PO, Fan L, Wang Z, Kennedy A, Kuhre RE, Christophersen P, Bardonnet PL, Sassene PJ. Rebollo R, et al. Among authors: pedersen hd. J Control Release. 2025 Jan 10;377:267-276. doi: 10.1016/j.jconrel.2024.11.036. Epub 2024 Nov 21. J Control Release. 2025. PMID: 39566853 Free article.
Cephalopod-inspired jetting devices for gastrointestinal drug delivery.
Arrick G, Sticker D, Ghazal A, Lu Y, Duncombe T, Gwynne D, Mouridsen B, Wainer J, Jepsen JPH, Last TS, Schultz D, Hess K, Medina De Alba E, Min S, Poulsen M, Anker C, Karandikar P, Pedersen HD, Collins J, Egecioglu NE, Tamang S, Cleveland C, Ishida K, Uhrenfeldt AH, Kuosmanen J, Pereverzina M, Hayward A, Kirk RK, You S, Dalsgaard CM, Gunnarsson SB, Patsi I, Bohr A, Azzarello A, Frederiksen MR, Herskind P, Li J, Roxhed N, Rahbek UL, Water JJ, Buckley ST, Traverso G. Arrick G, et al. Among authors: pedersen hd. Nature. 2024 Dec;636(8042):481-487. doi: 10.1038/s41586-024-08202-5. Epub 2024 Nov 20. Nature. 2024. PMID: 39567682 Free PMC article.
Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs.
Schultz D, Kempen PJ, Primdahl S, Pereverzina M, Uhrenfeldt AH, Alba EMD, Andreasen J, Pedersen HD, Cleveland C, Duncombe T, Ahnfelt-Ro Nne J, Kirk RK, Pfander IB, Sticker D, Water JJ, Buckley ST, Andresen TL, Urquhart AJ. Schultz D, et al. Among authors: pedersen hd. ACS Appl Mater Interfaces. 2024 Dec 11;16(49):67192-67202. doi: 10.1021/acsami.4c11819. Epub 2024 Dec 2. ACS Appl Mater Interfaces. 2024. PMID: 39621822
Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model.
Lützhøft DO, Sinioja T, Christoffersen BØ, Jakobsen RR, Geng D, Ahmad HFB, Straarup EM, Pedersen KM, Kot W, Pedersen HD, Cirera S, Hyötyläinen T, Nielsen DS, Hansen AK. Lützhøft DO, et al. Among authors: pedersen hd. BMC Microbiol. 2022 Dec 1;22(1):287. doi: 10.1186/s12866-022-02704-w. BMC Microbiol. 2022. PMID: 36456963 Free PMC article.
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period.
Hvid H, Hjuler ST, Bedossa P, Tiniakos DG, Kamzolas I, Harder LM, Xue Y, Perfield JW, Kirk RK, Latta M, Mikkelsen LF, Pedersen HD; LITMUS Investigators. Hvid H, et al. Among authors: pedersen hd. Am J Physiol Gastrointest Liver Physiol. 2024 Oct 1;327(4):G571-G585. doi: 10.1152/ajpgi.00120.2024. Epub 2024 Jul 23. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 39041677 Free PMC article.
High fat diet is associated with gut microbiota dysbiosis and decreased gut microbial derived metabolites related to metabolic health in young Göttingen Minipigs.
Lützhøft DO, Bækgård C, Wimborne E, Straarup EM, Pedersen KM, Swann JR, Pedersen HD, Kristensen K, Morgills L, Nielsen DS, Hansen AK, Bracken MK, Cirera S, Christoffersen BØ. Lützhøft DO, et al. Among authors: pedersen hd. PLoS One. 2024 Mar 1;19(3):e0298602. doi: 10.1371/journal.pone.0298602. eCollection 2024. PLoS One. 2024. PMID: 38427692 Free PMC article.
Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy.
Christoffersen BØ, Kristensen CA, Lindgaard R, Kirk RK, Viuff BM, Kvist PH, Pedersen HD, Ludvigsen TP, Skovgaard T, Fels JJ, Martinussen T, Christiansen LB, Cirera S, Olsen LH. Christoffersen BØ, et al. Among authors: pedersen hd. Sci Rep. 2023 Apr 12;13(1):6017. doi: 10.1038/s41598-023-32674-6. Sci Rep. 2023. PMID: 37045950 Free PMC article.
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia.
Carlsen MF, Christoffersen BØ, Lindgaard R, Pedersen HD, Olsen LH. Carlsen MF, et al. Among authors: pedersen hd. J Pharmacol Toxicol Methods. 2022 May-Jun;115:107168. doi: 10.1016/j.vascn.2022.107168. Epub 2022 Mar 18. J Pharmacol Toxicol Methods. 2022. PMID: 35315338 Free article.
Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity.
Feng Y, Cirera S, Taşöz E, Liu Y, Olsen LH, Christoffersen BØ, Pedersen HD, Ludvigsen TP, Kirk RK, Schumacher-Petersen C, Deng Y, Fredholm M, Gao F. Feng Y, et al. Among authors: pedersen hd. Front Genet. 2021 Mar 11;12:632859. doi: 10.3389/fgene.2021.632859. eCollection 2021. Front Genet. 2021. PMID: 33777102 Free PMC article.
NASH-inducing Diets in Göttingen Minipigs.
Pedersen HD, Galsgaard ED, Christoffersen BØ, Cirera S, Holst D, Fredholm M, Latta M. Pedersen HD, et al. J Clin Exp Hepatol. 2020 May-Jun;10(3):211-221. doi: 10.1016/j.jceh.2019.09.004. Epub 2019 Sep 21. J Clin Exp Hepatol. 2020. PMID: 32405177 Free PMC article.
91 results