Liggett SB - Search Results

1

Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5.

Young Yang M, Duy Mac K, Strzelinski HR, Hoffman SA, Kim D, Kim SK, Su J, Liggett SB, Goddard WA 3rd. Young Yang M, et al. Among authors: liggett sb. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2409987121. doi: 10.1073/pnas.2409987121. Epub 2024 Nov 20. Proc Natl Acad Sci U S A. 2024. PMID: 39565310

2

Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.

Yang MY, Kim SK, Kim D, Liggett SB, Goddard WA 3rd. Yang MY, et al. Among authors: liggett sb. J Phys Chem Lett. 2021 Sep 30;12(38):9293-9300. doi: 10.1021/acs.jpclett.1c02162. Epub 2021 Sep 20. J Phys Chem Lett. 2021. PMID: 34542294 Free PMC article.

3

Identification and characterization of an atypical Gαs-biased β₂AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.

Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA 3rd, Liggett SB. Kim D, et al. Among authors: liggett sb. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2026668118. doi: 10.1073/pnas.2026668118. Proc Natl Acad Sci U S A. 2021. PMID: 34857633 Free PMC article.

4

α_1B/D-adrenoceptors regulate chemokine receptor-mediated leukocyte migration via formation of heteromeric receptor complexes.

Enten GA, Gao X, Strzelinski HR, Weche M, Liggett SB, Majetschak M. Enten GA, et al. Among authors: liggett sb. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2123511119. doi: 10.1073/pnas.2123511119. Epub 2022 May 10. Proc Natl Acad Sci U S A. 2022. PMID: 35537053 Free PMC article.

5

Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development.

Kim D, Tokmakova A, Woo JA, An SS, Goddard WA 3rd, Liggett SB. Kim D, et al. Among authors: liggett sb. Mol Diagn Ther. 2022 Jul;26(4):383-396. doi: 10.1007/s40291-022-00592-4. Epub 2022 May 20. Mol Diagn Ther. 2022. PMID: 35595932 Free PMC article. Review.

6

Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease.

Tokmakova A, Kim D, Goddard WA 3rd, Liggett SB. Tokmakova A, et al. Among authors: liggett sb. J Pers Med. 2022 Feb 22;12(3):331. doi: 10.3390/jpm12030331. J Pers Med. 2022. PMID: 35330331 Free PMC article. Review.

7

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators.

Gin A, Nguyen PD, Melzer JE, Li C, Strzelinski H, Liggett SB, Su J. Gin A, et al. Among authors: liggett sb. Nat Commun. 2024 Aug 28;15(1):7445. doi: 10.1038/s41467-024-51320-x. Nat Commun. 2024. PMID: 39198447 Free PMC article.

8

Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G_αi1,2,3.

Kim D, Woo JA, Geffken E, An SS, Liggett SB. Kim D, et al. Among authors: liggett sb. Am J Respir Cell Mol Biol. 2017 Jun;56(6):762-771. doi: 10.1165/rcmb.2016-0373OC. Am J Respir Cell Mol Biol. 2017. PMID: 28145731 Free PMC article.

9

Differential long-term regulation of TAS2R14 by structurally distinct agonists.

Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Woo JA, et al. Among authors: liggett sb. FASEB J. 2019 Nov;33(11):12213-12225. doi: 10.1096/fj.201802627RR. Epub 2019 Aug 20. FASEB J. 2019. PMID: 31430434 Free PMC article.

10

β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function.

Kim D, Pauer SH, Yong HM, An SS, Liggett SB. Kim D, et al. Among authors: liggett sb. J Biol Chem. 2016 Aug 19;291(34):17616-28. doi: 10.1074/jbc.M116.722736. Epub 2016 Jun 24. J Biol Chem. 2016. PMID: 27342779 Free PMC article.

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