Sims EK - Search Results

1

Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab.

Galderisi A, Sims EK, Evans-Molina C, Petrelli A, Cuthbertson D, Nathan BM, Ismail HM, Herold KC, Moran A. Galderisi A, et al. Among authors: sims ek. Diabetologia. 2024 Nov 19. doi: 10.1007/s00125-024-06323-0. Online ahead of print. Diabetologia. 2024. PMID: 39560746

2

High proinsulin:C-peptide ratio identifies individuals with stage 2 type 1 diabetes at high risk for progression to clinical diagnosis and responses to teplizumab treatment.

Sims EK, Geyer SM, Long SA, Herold KC. Sims EK, et al. Diabetologia. 2023 Dec;66(12):2283-2291. doi: 10.1007/s00125-023-06003-5. Epub 2023 Sep 4. Diabetologia. 2023. PMID: 37667106 Free PMC article.

3

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.

Sims EK, Lakhter AJ, Anderson-Baucum E, Kono T, Tong X, Evans-Molina C. Sims EK, et al. Diabetologia. 2017 Jun;60(6):1057-1065. doi: 10.1007/s00125-017-4237-z. Epub 2017 Mar 9. Diabetologia. 2017. PMID: 28280903 Free PMC article.

4

Biomarkers of islet beta cell stress and death in type 1 diabetes.

Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG. Sims EK, et al. Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15. Diabetologia. 2018. PMID: 30112687 Free PMC article. Review.

5

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

Oram RA, Sims EK, Evans-Molina C. Oram RA, et al. Among authors: sims ek. Diabetologia. 2019 Apr;62(4):567-577. doi: 10.1007/s00125-019-4822-4. Epub 2019 Feb 14. Diabetologia. 2019. PMID: 30767048 Free PMC article. Review.

6

The role of beta-cell dysfunction in early type 1 diabetes.

Sims EK, Mirmira RG, Evans-Molina C. Sims EK, et al. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):215-224. doi: 10.1097/MED.0000000000000548. Curr Opin Endocrinol Diabetes Obes. 2020. PMID: 32618633 Free PMC article. Review.

7

Index60 as an additional diagnostic criterion for type 1 diabetes.

Redondo MJ, Nathan BM, Jacobsen LM, Sims E, Bocchino LE, Pugliese A, Schatz DA, Atkinson MA, Skyler J, Palmer J, Geyer S, Sosenko JM; Type 1 diabetes TrialNet Study Group. Redondo MJ, et al. Diabetologia. 2021 Apr;64(4):836-844. doi: 10.1007/s00125-020-05365-4. Epub 2021 Jan 26. Diabetologia. 2021. PMID: 33496819 Free PMC article.

8

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals.

Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC; Type 1 Diabetes TrialNet Study Group. Sims EK, et al. Sci Transl Med. 2021 Mar 3;13(583):eabc8980. doi: 10.1126/scitranslmed.abc8980. Sci Transl Med. 2021. PMID: 33658358 Free PMC article. Clinical Trial.

9

The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes.

Sims EK, Cuthbertson D, Herold KC, Sosenko JM. Sims EK, et al. Diabetes. 2021 Dec;70(12):2922-2931. doi: 10.2337/db21-0519. Epub 2021 Sep 22. Diabetes. 2021. PMID: 34551936 Free PMC article. Clinical Trial.

10

Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.

Sims EK, Cuthbertson D, Felton JL, Ismail HM, Nathan BM, Jacobsen LM, Paprocki E, Pugliese A, Palmer J, Atkinson M, Evans-Molina C, Skyler JS, Redondo MJ, Herold KC, Sosenko JM. Sims EK, et al. Diabetes Care. 2022 Dec 1;45(12):2982-2990. doi: 10.2337/dc22-1362. Diabetes Care. 2022. PMID: 36326757 Free PMC article.

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