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Page 1
The tyrosine kinase Yes1 is a druggable host factor of HEV.
Haase JA, Baheerathan A, Zhang X, Fu RM, Nocke MK, Decker C, Dao Thi VL, Todt D, Neyts J, Kaptein SJF, Steinmann E, Kinast V. Haase JA, et al. Among authors: kinast v. Hepatol Commun. 2024 Oct 17;8(11):e0553. doi: 10.1097/HC9.0000000000000553. eCollection 2024 Nov 1. Hepatol Commun. 2024. PMID: 39560373 Free PMC article.
A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook AW, Bauer M, Hoffmann HH, Pinharanda A, Ricardo-Lax I, Stenzel AF, Rosado-Olivieri EA, Dinnon KH 3rd, Doyle WC, Freije CA, Hong SH, Lee D, Lewy T, Luna JM, Peace A, Schmidt C, Schneider WM, Winkler R, Yip EZ, Larson C, McGinn T, Menezes MR, Ramos-Espiritu L, Banerjee P, Poirier JT, Sànchez-Rivera FJ, Cobat A, Zhang Q, Casanova JL, Carroll TS, Glickman JF, Michailidis E, Razooky B, MacDonald MR, Rice CM. Le Pen J, et al. Among authors: kinast v. PLoS Biol. 2024 Sep 24;22(9):e3002767. doi: 10.1371/journal.pbio.3002767. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39316623 Free PMC article.
The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle.
Reichert I, Lee JY, Weber L, Fuh MM, Schlaeger L, Rößler S, Kinast V, Schlienkamp S, Conradi J, Vondran FWR, Pfaender S, Scaturro P, Steinmann E, Bartenschlager R, Pietschmann T, Heeren J, Lauber C, Vieyres G. Reichert I, et al. Among authors: kinast v. PLoS Pathog. 2024 Sep 6;20(9):e1012509. doi: 10.1371/journal.ppat.1012509. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39241103 Free PMC article.
Targeting cellular cathepsins inhibits hepatitis E virus entry.
Klöhn M, Burkard T, Janzen J, Haase JA, Gömer A, Fu R, Ssebyatika G, Nocke MK, Brown RJP, Krey T, Dao Thi VL, Kinast V, Brüggemann Y, Todt D, Steinmann E. Klöhn M, et al. Among authors: kinast v. Hepatology. 2024 Nov 1;80(5):1239-1251. doi: 10.1097/HEP.0000000000000912. Epub 2024 May 10. Hepatology. 2024. PMID: 38728662 Free PMC article.
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E. Kinast V, et al. Antiviral Res. 2023 Sep;217:105690. doi: 10.1016/j.antiviral.2023.105690. Epub 2023 Jul 28. Antiviral Res. 2023. PMID: 37517633 Free article.
EGF receptor modulates HEV entry in human hepatocytes.
Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E. Schrader JA, et al. Among authors: kinast v. Hepatology. 2023 Jun 1;77(6):2104-2117. doi: 10.1097/HEP.0000000000000308. Epub 2023 Feb 7. Hepatology. 2023. PMID: 36745934 Free PMC article.
25 results