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Page 1
Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients.
Neefjes M, Housmans BAC, Kaffa C, Thielen NGM, Joosten LAB, van den Ende CHM, Vitters EL, van den Akker GGH, Welting TJM, van Caam APM, van der Kraan PM. Neefjes M, et al. Among authors: thielen ngm. Rheumatology (Oxford). 2024 Nov 18:keae555. doi: 10.1093/rheumatology/keae555. Online ahead of print. Rheumatology (Oxford). 2024. PMID: 39558621
Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.
Thielen NGM, van Caam APM, V Beuningen HM, Vitters EL, van den Bosch MHJ, Koenders MI, van de Loo FAJ, Blaney Davidson EN, van der Kraan PM. Thielen NGM, et al. Osteoarthritis Cartilage. 2023 Nov;31(11):1481-1490. doi: 10.1016/j.joca.2023.08.004. Epub 2023 Aug 29. Osteoarthritis Cartilage. 2023. PMID: 37652257 Free article.
Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants.
Vago JP, Valdrighi N, Blaney-Davidson EN, Hornikx DLAH, Neefjes M, Barba-Sarasua ME, Thielen NGM, van den Bosch MHJ, van der Kraan PM, Koenders MI, Amaral FA, van de Loo FAJ. Vago JP, et al. Among authors: thielen ngm. Pharmaceuticals (Basel). 2023 May 6;16(5):703. doi: 10.3390/ph16050703. Pharmaceuticals (Basel). 2023. PMID: 37242486 Free PMC article.
Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression.
Wiegertjes R, Thielen NGM, van Caam APM, van Laar M, van Beuningen HM, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ, Blaney Davidson EN. Wiegertjes R, et al. Among authors: thielen ngm. Osteoarthritis Cartilage. 2021 May;29(5):773-782. doi: 10.1016/j.joca.2021.01.008. Epub 2021 Feb 20. Osteoarthritis Cartilage. 2021. PMID: 33617971 Free article.