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Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation.
Oz S, Keren-Raifman T, Sharon T, Subramaniam S, Pallien T, Katz M, Tsemakhovich V, Sholokh A, Watad B, Tripathy DR, Sasson G, Chomsky-Hecht O, Vysochek L, Schulz-Christian M, Fecher-Trost C, Zühlke K, Bertinetti D, Herberg FW, Flockerzi V, Hirsch JA, Klussmann E, Weiss S, Dascal N. Oz S, et al. Among authors: bertinetti d. BMC Biol. 2024 Nov 28;22(1):276. doi: 10.1186/s12915-024-02076-9. BMC Biol. 2024. PMID: 39609812 Free PMC article.
A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.
Steiner WP, Iverson N, Venkatakrishnan V, Wu J, Stepniewski TM, Michaelson Z, Bröckel JW, Zhu JF, Bruystens J, Lee A, Nelson I, Bertinetti D, Arveseth CD, Tan G, Spaltenstein P, Xu J, Hüttenhain R, Kay M, Herberg FW, Selent J, Anand GS, Dunbrack RL Jr, Taylor SS, Myers BR. Steiner WP, et al. Among authors: bertinetti d. bioRxiv [Preprint]. 2024 Nov 1:2024.10.31.621410. doi: 10.1101/2024.10.31.621410. bioRxiv. 2024. PMID: 39554190 Free PMC article. Preprint.
Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW.
Störmer E, Weng JH, Wu J, Bertinetti D, Kaila Sharma P, Ma W, Herberg FW, Taylor S. Störmer E, et al. Among authors: bertinetti d. Biochem J. 2023 May 22;480(11):815-33. doi: 10.1042/BCJ20230126. Online ahead of print. Biochem J. 2023. PMID: 37212165 Free PMC article.
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, Veglia G, Herberg FW, Taylor SS, Myers BR. Happ JT, et al. Among authors: bertinetti d. Nat Struct Mol Biol. 2022 Oct;29(10):990-999. doi: 10.1038/s41594-022-00838-z. Epub 2022 Oct 6. Nat Struct Mol Biol. 2022. PMID: 36202993 Free PMC article.
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skålhegg BS, Otaify GA, Temtamy S, Aglan M, Jønch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL. Palencia-Campos A, et al. Among authors: bertinetti d. Am J Hum Genet. 2020 Nov 5;107(5):977-988. doi: 10.1016/j.ajhg.2020.09.005. Epub 2020 Oct 14. Am J Hum Genet. 2020. PMID: 33058759 Free PMC article.
Molecular Basis for Ser/Thr Specificity in PKA Signaling.
Knape MJ, Wallbott M, Burghardt NCG, Bertinetti D, Hornung J, Schmidt SH, Lorenz R, Herberg FW. Knape MJ, et al. Among authors: bertinetti d. Cells. 2020 Jun 25;9(6):1548. doi: 10.3390/cells9061548. Cells. 2020. PMID: 32630525 Free PMC article.
40 results