Kalkreuter E - Search Results

1

Structural Insights into the Mechanism of a Polyketide Synthase Thiocysteine Lyase Domain.

Steele AD, Meng S, Li G, Kalkreuter E, Chang C, Shen B. Steele AD, et al. Among authors: kalkreuter e. J Am Chem Soc. 2024 Nov 27;146(47):32605-32617. doi: 10.1021/jacs.4c11656. Epub 2024 Nov 15. J Am Chem Soc. 2024. PMID: 39546807

2

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

Kalkreuter E, CroweTipton JM, Lowell AN, Sherman DH, Williams GJ. Kalkreuter E, et al. J Am Chem Soc. 2019 Feb 6;141(5):1961-1969. doi: 10.1021/jacs.8b10521. Epub 2019 Jan 24. J Am Chem Soc. 2019. PMID: 30676722 Free PMC article.

3

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

Dong LB, Zhang X, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H, Shen B. Dong LB, et al. Among authors: kalkreuter e. J Am Chem Soc. 2019 Mar 6;141(9):4043-4050. doi: 10.1021/jacs.8b13452. Epub 2019 Feb 19. J Am Chem Soc. 2019. PMID: 30735041 Free PMC article.

4

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis.

Dong LB, Liu YC, Cepeda AJ, Kalkreuter E, Deng MR, Rudolf JD, Chang C, Joachimiak A, Phillips GN Jr, Shen B. Dong LB, et al. Among authors: kalkreuter e. J Am Chem Soc. 2019 Aug 7;141(31):12406-12412. doi: 10.1021/jacs.9b06183. Epub 2019 Jul 23. J Am Chem Soc. 2019. PMID: 31291107 Free PMC article.

5

Targeting Bacterial Genomes for Natural Product Discovery.

Kalkreuter E, Pan G, Cepeda AJ, Shen B. Kalkreuter E, et al. Trends Pharmacol Sci. 2020 Jan;41(1):13-26. doi: 10.1016/j.tips.2019.11.002. Epub 2019 Dec 7. Trends Pharmacol Sci. 2020. PMID: 31822352 Free PMC article. Review.

6

PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases.

Zheng CJ, Kalkreuter E, Fan BY, Liu YC, Dong LB, Shen B. Zheng CJ, et al. Among authors: kalkreuter e. ACS Chem Biol. 2021 Jan 15;16(1):96-105. doi: 10.1021/acschembio.0c00773. Epub 2020 Dec 14. ACS Chem Biol. 2021. PMID: 33314918 Free PMC article.

7

Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis.

Cao M, Zheng C, Yang D, Kalkreuter E, Adhikari A, Liu YC, Rateb ME, Shen B. Cao M, et al. Among authors: kalkreuter e. Angew Chem Int Ed Engl. 2021 Mar 22;60(13):7140-7147. doi: 10.1002/anie.202015570. Epub 2021 Feb 17. Angew Chem Int Ed Engl. 2021. PMID: 33465268 Free PMC article.

8

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase.

Kalkreuter E, Bingham KS, Keeler AM, Lowell AN, Schmidt JJ, Sherman DH, Williams GJ. Kalkreuter E, et al. Nat Commun. 2021 Apr 13;12(1):2193. doi: 10.1038/s41467-021-22497-2. Nat Commun. 2021. PMID: 33850151 Free PMC article.

9

Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase.

Meng S, Steele AD, Yan W, Pan G, Kalkreuter E, Liu YC, Xu Z, Shen B. Meng S, et al. Among authors: kalkreuter e. Nat Commun. 2021 Sep 28;12(1):5672. doi: 10.1038/s41467-021-25798-8. Nat Commun. 2021. PMID: 34584078 Free PMC article.

10

Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis.

Gui C, Kalkreuter E, Liu YC, Adhikari A, Teijaro CN, Yang D, Chang C, Shen B. Gui C, et al. Among authors: kalkreuter e. J Am Chem Soc. 2022 Nov 9;144(44):20452-20462. doi: 10.1021/jacs.2c08957. Epub 2022 Oct 24. J Am Chem Soc. 2022. PMID: 36279548 Free PMC article.

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