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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.
Zhou Y, Aliagas I, Wang S, Li CS, Liu Z, Bowman CM, Burdick DJ, Clark KR, Dening TJ, Flygare J, Ganti A, Girgis HS, Hanan EJ, Harris SF, Hu C, Kapadia SB, Koehler MFT, Lai T, Liang J, Liu X, Ma F, Mao J, Nicolai J, Sims J, Unhayaker S, Wai J, Wang X, Wu P, Xu Y, Yen CW, Zhang R, Elfert TF, Tan MW, Kofoed EM, Crawford TD. Zhou Y, et al. Among authors: kofoed em. Bioorg Med Chem Lett. 2025 Mar 1;117:130026. doi: 10.1016/j.bmcl.2024.130026. Epub 2024 Nov 12. Bioorg Med Chem Lett. 2025. PMID: 39536836
Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.
Kofoed EM, Aliagas I, Crawford T, Mao J, Harris SF, Xu M, Wang S, Wu P, Ma F, Clark K, Sims J, Xu Y, Peng Y, Skippington E, Yang Y, Reeder J, Ubhayakar S, Baumgardner M, Yan Z, Chen J, Park S, Zhang H, Yen C-W, Lorenzo M, Skelton N, Liang X, Chen L, Hoag B, Li CS, Liu Z, Wai J, Liu X, Liang J, Tan MW. Kofoed EM, et al. mBio. 2024 Oct 16;15(10):e0089724. doi: 10.1128/mbio.00897-24. Epub 2024 Aug 29. mBio. 2024. PMID: 39207111 Free PMC article.
Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli.
Peng Y, Moffat JG, DuPai C, Kofoed EM, Skippington E, Modrusan Z, Gloor SL, Clark K, Xu Y, Li S, Chen L, Liu X, Wu P, Harris SF, Wang S, Crawford TD, Li CS, Liu Z, Wai J, Tan M-W. Peng Y, et al. Among authors: kofoed em. J Bacteriol. 2024 Oct 24;206(10):e0010224. doi: 10.1128/jb.00102-24. Epub 2024 Sep 5. J Bacteriol. 2024. PMID: 39235234 Free PMC article.
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM. Luchetti G, et al. Among authors: kofoed em. Cell Host Microbe. 2021 Oct 13;29(10):1521-1530.e10. doi: 10.1016/j.chom.2021.08.010. Epub 2021 Sep 6. Cell Host Microbe. 2021. PMID: 34492225 Free PMC article.
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.
Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL. Morisaki JH, et al. Among authors: kofoed em. mBio. 2016 Sep 6;7(5):e00412-16. doi: 10.1128/mBio.00412-16. mBio. 2016. PMID: 27601569 Free PMC article.
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