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Intranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Poston TB, Girardi J, Kim M, Zwarycz P, Polson AG, Yount KS, Hanlan C, Jaras Salas I, Lammert SM, Arroyo D, Bruno T, Wu M, Rozzelle J, Fairman J, Esser-Kahn AP, Darville T. Poston TB, et al. Among authors: jaras salas i. Vaccine. 2025 Jan 1;43(Pt 1):126526. doi: 10.1016/j.vaccine.2024.126526. Epub 2024 Nov 12. Vaccine. 2025. PMID: 39536454 Free article.
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naïve mice.
Poston TB, Girardi J, Polson AG, Bhardwaj A, Yount KS, Jaras Salas I, Trim LK, Li Y, O'Connell CM, Leahy D, Harris JM, Beagley KW, Goonetilleke N, Darville T. Poston TB, et al. Among authors: jaras salas i. Mucosal Immunol. 2024 Oct;17(5):1005-1018. doi: 10.1016/j.mucimm.2024.06.012. Epub 2024 Jul 3. Mucosal Immunol. 2024. PMID: 38969067 Free PMC article.