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Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.
Pinzi L, Conze C, Bisi N, Torre GD, Soliman A, Monteiro-Abreu N, Trushina NI, Krusenbaum A, Dolouei MK, Hellwig A, Christodoulou MS, Passarella D, Bakota L, Rastelli G, Brandt R. Pinzi L, et al. Nat Commun. 2024 Feb 23;15(1):1679. doi: 10.1038/s41467-024-45851-6. Nat Commun. 2024. PMID: 38396035 Free PMC article.
Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase.
Tinivella A, Banchi M, Gambacorta G, Borghi F, Orlandi P, Baxendale IR, Di Paolo A, Bocci G, Pinzi L, Rastelli G. Tinivella A, et al. Among authors: pinzi l. ACS Pharmacol Transl Sci. 2023 Nov 23;6(12):1870-1883. doi: 10.1021/acsptsci.3c00183. eCollection 2023 Dec 8. ACS Pharmacol Transl Sci. 2023. PMID: 38093846 Free PMC article.
Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
Tinivella A, Nwachukwu JC, Angeli A, Foschi F, Benatti AL, Pinzi L, Izard T, Ferraroni M, Erumbi R, Christodoulou MS, Passarella D, Supuran CT, Nettles KW, Rastelli G. Tinivella A, et al. Among authors: pinzi l. Eur J Med Chem. 2023 Jan 15;246:115011. doi: 10.1016/j.ejmech.2022.115011. Epub 2022 Dec 6. Eur J Med Chem. 2023. PMID: 36516582 Free article.
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