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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981.
Sharma R, Sharma S, Shriwas P, Mehta L, Vu AH, Mouw JK, Koo J, Huang C, Matsuk VY, Tucker-Burden C, Joseph G, Behera M, Sun SY, Roy MA, Gilbert-Ross M, Leal T, Marcus AI, Shanmugam M. Sharma R, et al. Among authors: marcus ai. iScience. 2024 Oct 11;27(11):111133. doi: 10.1016/j.isci.2024.111133. eCollection 2024 Nov 15. iScience. 2024. PMID: 39524367 Free PMC article.
Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.
Seong CS, Huang C, Boese AC, Hou Y, Koo J, Mouw JK, Rupji M, Joseph G, Johnston HR, Claussen H, Switchenko JM, Behera M, Churchman M, Kolesar JM, Arnold SM, Kerrigan K, Akerley W, Colman H, Johns MA, Arciero C, Zhou W, Marcus AI, Ramalingam SS, Fu H, Gilbert-Ross M. Seong CS, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525772. doi: 10.1101/2023.01.26.525772. bioRxiv. 2023. PMID: 36747658 Free PMC article. Preprint.
Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Koo J, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544941. doi: 10.1101/2023.06.14.544941. bioRxiv. 2023. Update in: Cancer Res. 2024 Nov 15;84(22):3761-3771. doi: 10.1158/0008-5472.CAN-23-2631 PMID: 37398244 Free PMC article. Updated. Preprint.
A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.
Khatib TO, Amanso AM, Pedro B, Knippler CM, Summerbell ER, Zohbi NM, Konen JM, Mouw JK, Marcus AI. Khatib TO, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2023 Mar 1:2023.02.28.530493. doi: 10.1101/2023.02.28.530493. bioRxiv. 2023. Update in: PLoS One. 2023 Oct 11;18(10):e0292554. doi: 10.1371/journal.pone.0292554 PMID: 36909653 Free PMC article. Updated. Preprint.
Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK.
Samson SC, Rojas A, Zitnay RG, Carney KR, Hettinga W, Schaelling MC, Sicard D, Zhang W, Gilbert-Ross M, Dy GK, Cavnar MJ, Furqan M, Browning RF Jr, Naqash AR, Schneider BP, Tarhini A, Tschumperlin DJ, Venosa A, Marcus AI, Emerson LL, Spike BT, Knudsen BS, Mendoza MC. Samson SC, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2024 Sep 21:2024.09.17.613509. doi: 10.1101/2024.09.17.613509. bioRxiv. 2024. PMID: 39345541 Free PMC article. Preprint.
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export.
Tripathi BK, Hirsh NH, Qian X, Durkin ME, Wang D, Papageorge AG, Lake R, Evrard YA, Marcus AI, Ramalingam SS, Dasso M, Vousden KH, Doroshow JH, Walters KJ, Lowy DR. Tripathi BK, et al. Among authors: marcus ai. Nat Cancer. 2024 Dec;5(12):1902-1918. doi: 10.1038/s43018-024-00847-5. Epub 2024 Nov 11. Nat Cancer. 2024. PMID: 39528835 Free PMC article.
83 results