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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981.
Sharma R, Sharma S, Shriwas P, Mehta L, Vu AH, Mouw JK, Koo J, Huang C, Matsuk VY, Tucker-Burden C, Joseph G, Behera M, Sun SY, Roy MA, Gilbert-Ross M, Leal T, Marcus AI, Shanmugam M. Sharma R, et al. Among authors: koo j. iScience. 2024 Oct 11;27(11):111133. doi: 10.1016/j.isci.2024.111133. eCollection 2024 Nov 15. iScience. 2024. PMID: 39524367 Free PMC article.
Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.
Seong CS, Huang C, Boese AC, Hou Y, Koo J, Mouw JK, Rupji M, Joseph G, Johnston HR, Claussen H, Switchenko JM, Behera M, Churchman M, Kolesar JM, Arnold SM, Kerrigan K, Akerley W, Colman H, Johns MA, Arciero C, Zhou W, Marcus AI, Ramalingam SS, Fu H, Gilbert-Ross M. Seong CS, et al. Among authors: koo j. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525772. doi: 10.1101/2023.01.26.525772. bioRxiv. 2023. PMID: 36747658 Free PMC article. Preprint.
Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Koo J, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544941. doi: 10.1101/2023.06.14.544941. bioRxiv. 2023. Update in: Cancer Res. 2024 Nov 15;84(22):3761-3771. doi: 10.1158/0008-5472.CAN-23-2631 PMID: 37398244 Free PMC article. Updated. Preprint.
Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.
Gilbert-Ross M, Konen J, Koo J, Shupe J, Robinson BS, Wiles WG 4th, Huang C, Martin WD, Behera M, Smith GH, Hill CE, Rossi MR, Sica GL, Rupji M, Chen Z, Kowalski J, Kasinski AL, Ramalingam SS, Fu H, Khuri FR, Zhou W, Marcus AI. Gilbert-Ross M, et al. Among authors: koo j. JCI Insight. 2017 Mar 9;2(5):e90487. doi: 10.1172/jci.insight.90487. JCI Insight. 2017. PMID: 28289710 Free PMC article.
2,557 results