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Page 1
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.
Panek D, Pasieka A, Jończyk J, Gawlińska M, Zaręba P, Siwek A, Wolak M, Mordyl B, Głuch-Lutwin M, Latacz G, Brazzolotto X, Chantegreil F, Nachon F, Zdarova Karasova J, Pejchal J, Mzik M, Sestak V, Prchal L, Odvarkova J, Soukup O, Korabecny J, Sorf A, Hamsikova M, Zemanova L, Muckova L, Vánova N, Dryja P, Sałat K, Höfner G, Wanner K, Więckowska A, Malawska B. Panek D, et al. Among authors: latacz g. Angew Chem Int Ed Engl. 2024 Nov 11:e202420510. doi: 10.1002/anie.202420510. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39523866
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.
Kurczab R, Ali W, Łażewska D, Kotańska M, Jastrzębska-Więsek M, Satała G, Więcek M, Lubelska A, Latacz G, Partyka A, Starek M, Dąbrowska M, Wesołowska A, Jacob C, Kieć-Kononowicz K, Handzlik J. Kurczab R, et al. Among authors: latacz g. Molecules. 2018 Oct 3;23(10):2529. doi: 10.3390/molecules23102529. Molecules. 2018. PMID: 30282913 Free PMC article.
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Ali W, Spengler G, Kincses A, Nové M, Battistelli C, Latacz G, Starek M, Dąbrowska M, Honkisz-Orzechowska E, Romanelli A, Rasile MM, Szymańska E, Jacob C, Zwergel C, Handzlik J. Ali W, et al. Among authors: latacz g. Eur J Med Chem. 2020 Aug 15;200:112435. doi: 10.1016/j.ejmech.2020.112435. Epub 2020 May 15. Eur J Med Chem. 2020. PMID: 32505850
4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity.
Wágner G, Mocking TAM, Arimont M, Provensi G, Rani B, Silva-Marques B, Latacz G, Da Costa Pereira D, Karatzidou C, Vischer HF, Wijtmans M, Kieć-Kononowicz K, de Esch IJP, Leurs R. Wágner G, et al. Among authors: latacz g. J Med Chem. 2019 Dec 12;62(23):10848-10866. doi: 10.1021/acs.jmedchem.9b01462. Epub 2019 Nov 20. J Med Chem. 2019. PMID: 31675226 Free PMC article.
An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells.
Żesławska E, Kucwaj-Brysz K, Kincses A, Spengler G, Szymańska E, Czopek A, Marć MA, Kaczor A, Nitek W, Domínguez-Álvarez E, Latacz G, Kieć-Kononowicz K, Handzlik J. Żesławska E, et al. Among authors: latacz g. Bioorg Chem. 2021 Apr;109:104735. doi: 10.1016/j.bioorg.2021.104735. Epub 2021 Feb 18. Bioorg Chem. 2021. PMID: 33640632
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.
Więckowska A, Wichur T, Godyń J, Bucki A, Marcinkowska M, Siwek A, Więckowski K, Zaręba P, Knez D, Głuch-Lutwin M, Kazek G, Latacz G, Mika K, Kołaczkowski M, Korabecny J, Soukup O, Benkova M, Kieć-Kononowicz K, Gobec S, Malawska B. Więckowska A, et al. Among authors: latacz g. ACS Chem Neurosci. 2018 May 16;9(5):1195-1214. doi: 10.1021/acschemneuro.8b00024. Epub 2018 Feb 13. ACS Chem Neurosci. 2018. PMID: 29384656
Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives.
Szczepańska K, Karcz T, Kotańska M, Siwek A, Kuder KJ, Latacz G, Mogilski S, Hagenow S, Lubelska A, Sobolewski M, Stark H, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: latacz g. Bioorg Med Chem. 2018 Dec 15;26(23-24):6056-6066. doi: 10.1016/j.bmc.2018.11.010. Epub 2018 Nov 10. Bioorg Med Chem. 2018. PMID: 30448256
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
Ali W, Więcek M, Łażewska D, Kurczab R, Jastrzębska-Więsek M, Satała G, Kucwaj-Brysz K, Lubelska A, Głuch-Lutwin M, Mordyl B, Siwek A, Nasim MJ, Partyka A, Sudoł S, Latacz G, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Ali W, et al. Among authors: latacz g. Eur J Med Chem. 2019 Sep 15;178:740-751. doi: 10.1016/j.ejmech.2019.06.022. Epub 2019 Jun 10. Eur J Med Chem. 2019. PMID: 31229876
Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo.
Sudoł S, Kucwaj-Brysz K, Kurczab R, Wilczyńska N, Jastrzębska-Więsek M, Satała G, Latacz G, Głuch-Lutwin M, Mordyl B, Żesławska E, Nitek W, Partyka A, Buzun K, Doroz-Płonka A, Wesołowska A, Bielawska A, Handzlik J. Sudoł S, et al. Among authors: latacz g. Eur J Med Chem. 2020 Oct 1;203:112529. doi: 10.1016/j.ejmech.2020.112529. Epub 2020 Jul 6. Eur J Med Chem. 2020. PMID: 32693296 Free article.
132 results