Bertz RJ - Search Results

1

Comparative bioavailability of single-dose zavegepant during and between migraine attacks: A phase 1, randomized, open-label, fixed-sequence, two-period study.

Bertz RJ, Collins JL, Madonia J, Bhardwaj R, Kamen L, Matschke KT, Liu J. Bertz RJ, et al. Headache. 2024 Nov 7. doi: 10.1111/head.14856. Online ahead of print. Headache. 2024. PMID: 39508426

2

Rimegepant 75 mg in Subjects With Hepatic Impairment: Results of a Phase 1, Open-Label, Single-Dose, Parallel-Group Study.

Bhardwaj R, Ivans A, Stringfellow J, Morris B, Coric V, Croop R, Bertz R. Bhardwaj R, et al. Clin Pharmacol Drug Dev. 2023 Aug;12(8):790-800. doi: 10.1002/cpdd.1244. Epub 2023 Apr 18. Clin Pharmacol Drug Dev. 2023. PMID: 37073443 Clinical Trial.

3

Effects of rimegepant 75 mg daily on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate in healthy female participants.

Bhardwaj R, Stringfellow JC, Morris B, Croop RS, Bertz RJ. Bhardwaj R, et al. Among authors: bertz rj. Headache. 2023 May;63(5):652-662. doi: 10.1111/head.14512. Epub 2023 May 4. Headache. 2023. PMID: 37140071 Clinical Trial.

4

A placebo-controlled, randomized, single and multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of rimegepant in healthy participants.

Bertz R, Bhardwaj R, Morris BA, Ashbrenner E, Coric V, Croop R. Bertz R, et al. Cephalalgia. 2023 Jun;43(6):3331024231179131. doi: 10.1177/03331024231179131. Cephalalgia. 2023. PMID: 37282507 Free article. Clinical Trial.

5

The Pharmacokinetics, Safety, and Tolerability of Rimegepant 75 mg Are Similar in Elderly and Nonelderly Adults: A Phase 1, Open-Label, Parallel-Group, Single-Dose Study.

Bhardwaj R, Morris B, Bertz R, Croop R, Liu J. Bhardwaj R, et al. Clin Pharmacol Drug Dev. 2024 Jan;13(1):37-44. doi: 10.1002/cpdd.1337. Epub 2023 Oct 30. Clin Pharmacol Drug Dev. 2024. PMID: 37904724 Clinical Trial.

6

A Drug-Drug Interaction Study to Evaluate the Impact of Rimegepant on OCT2- and MATE1-Mediated Transport of Metformin in Healthy Participants.

Bhardwaj R, Morris B, Matschke K, Bertz R, Croop R, Liu J. Bhardwaj R, et al. Clin Pharmacol Drug Dev. 2024 May;13(5):465-473. doi: 10.1002/cpdd.1352. Epub 2024 Jan 4. Clin Pharmacol Drug Dev. 2024. PMID: 38174905 Clinical Trial.

7

Bioequivalence of rimegepant, a small molecule CGRP receptor antagonist, administered as an oral tablet, a sublingual orally disintegrating tablet, and a supralingual orally disintegrating tablet: two phase 1 randomized studies in healthy adults.

Croop R, Bhardwaj R, Anderson MS, Matschke KT, Hould J, Bertz R, Liu J, Lipton RB. Croop R, et al. Cephalalgia. 2024 Feb;44(2):3331024231219505. doi: 10.1177/03331024231219505. Cephalalgia. 2024. PMID: 38366390 Free article. Clinical Trial.

8

No clinically relevant electrocardiogram effects in a randomized TQT study of single therapeutic/supratherapeutic rimegepant doses in healthy adults.

Bhardwaj R, Hanna MS, Morris BA, Matschke KT, Bertz R, Croop RS, Liu J. Bhardwaj R, et al. Clin Transl Sci. 2024 Mar;17(3):e13727. doi: 10.1111/cts.13727. Clin Transl Sci. 2024. PMID: 38440916 Free PMC article. Clinical Trial.

9

Concentration-QTc and cardiac safety analysis of single and multiple zavegepant nasal spray doses in healthy participants to support approval.

Hughes JH, Bertz R, Bhardwaj R, Donohue MK, Madonia J, Anderson MS, Morris BA, Croop RS, Liu J. Hughes JH, et al. CPT Pharmacometrics Syst Pharmacol. 2024 Jun;13(6):1044-1054. doi: 10.1002/psp4.13140. Epub 2024 May 29. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38812357 Free PMC article. Clinical Trial.

10

Reduced hepatic impairment study to evaluate pharmacokinetics and safety of zavegepant and to inform dosing recommendation for hepatic impairment.

Bhardwaj R, Donohue MK, Madonia J, Morris B, Marbury TC, Matschke KT, Croop R, Bertz R, Liu J. Bhardwaj R, et al. Clin Transl Sci. 2024 Jul;17(7):e13813. doi: 10.1111/cts.13813. Clin Transl Sci. 2024. PMID: 39014555 Free PMC article. Clinical Trial.

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