Kinnunen PC - Search Results

1

Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells.

Kinnunen PC, Srivastava S, Wang Z, Ho KKY, Humphries BA, Chen S, Linderman JJ, Luker GD, Luker KE, Garikipati K. Kinnunen PC, et al. ArXiv [Preprint]. 2024 Oct 24:arXiv:2302.09445v2. ArXiv. 2024. PMID: 39502887 Free PMC article. Preprint.

2

Computational modeling implicates protein scaffolding in p38 regulation of Akt.

Kinnunen PC, Luker GD, Luker KE, Linderman JJ. Kinnunen PC, et al. J Theor Biol. 2022 Dec 21;555:111294. doi: 10.1016/j.jtbi.2022.111294. Epub 2022 Oct 1. J Theor Biol. 2022. PMID: 36195198 Free PMC article.

3

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways.

Ho KKY, Srivastava S, Kinnunen PC, Garikipati K, Luker GD, Luker KE. Ho KKY, et al. Among authors: kinnunen pc. Bioengineering (Basel). 2023 Feb 18;10(2):269. doi: 10.3390/bioengineering10020269. Bioengineering (Basel). 2023. PMID: 36829763 Free PMC article.

4

Computational methods for characterizing and learning from heterogeneous cell signaling data.

Kinnunen PC, Luker KE, Luker GD, Linderman JJ. Kinnunen PC, et al. Curr Opin Syst Biol. 2021 Jun;26:98-108. doi: 10.1016/j.coisb.2021.04.009. Epub 2021 May 4. Curr Opin Syst Biol. 2021. PMID: 35647414 Free PMC article.

5

Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays.

Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ. Kinnunen PC, et al. NPJ Syst Biol Appl. 2024 Apr 18;10(1):42. doi: 10.1038/s41540-024-00369-x. NPJ Syst Biol Appl. 2024. PMID: 38637530 Free PMC article.

6

Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling.

Spinosa PC, Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ. Spinosa PC, et al. Among authors: kinnunen pc. Cell Mol Bioeng. 2020 Jul 27;14(1):49-64. doi: 10.1007/s12195-020-00640-1. eCollection 2021 Feb. Cell Mol Bioeng. 2020. PMID: 33643466 Free PMC article.

7

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.

Makowski EK, Kinnunen PC, Huang J, Wu L, Smith MD, Wang T, Desai AA, Streu CN, Zhang Y, Zupancic JM, Schardt JS, Linderman JJ, Tessier PM. Makowski EK, et al. Among authors: kinnunen pc. Nat Commun. 2022 Jul 1;13(1):3788. doi: 10.1038/s41467-022-31457-3. Nat Commun. 2022. PMID: 35778381 Free PMC article.

8

Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling.

Fontana J, Sparkman-Yager D, Faulkner I, Cardiff R, Kiattisewee C, Walls A, Primo TG, Kinnunen PC, Garcia Martin H, Zalatan JG, Carothers JM. Fontana J, et al. Among authors: kinnunen pc. Nat Commun. 2024 Jul 27;15(1):6341. doi: 10.1038/s41467-024-50528-1. Nat Commun. 2024. PMID: 39068154 Free PMC article.

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