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Page 1
Identification of late-stage tau accumulation using plasma phospho-tau217.
Woo MS, Therriault J, Jonaitis EM, Wilson R, Langhough RE, Rahmouni N, Benedet AL, Ashton NJ, Tissot C, Lantero-Rodriguez J, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Betthauser TJ, Lussier FZ, Hopewell R, Triana-Baltzer G, Kolb HC, Jeromin A, Kobayashi E, Massarweh G, Friese MA, Klostranec J, Vilali P, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Johnson SC, Rosa-Neto P. Woo MS, et al. Among authors: hopewell r. EBioMedicine. 2024 Nov;109:105413. doi: 10.1016/j.ebiom.2024.105413. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500009 Free PMC article.
18F-MK-6240 PET for early and late detection of neurofibrillary tangles.
Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, Tissot C, Qureshi MNI, Kang MS, Mathotaarachchi S, Stevenson J, Hopewell R, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: hopewell r. Brain. 2020 Sep 1;143(9):2818-2830. doi: 10.1093/brain/awaa180. Brain. 2020. PMID: 32671408
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals.
Simrén J, Brum WS, Ashton NJ, Benedet AL, Karikari TK, Kvartsberg H, Sjons E, Lussier FZ, Chamoun M, Stevenson J, Hopewell R, Pallen V, Ye K, Pascoal TA, Zetterberg H, Rosa-Neto P, Blennow K. Simrén J, et al. Among authors: hopewell r. Alzheimers Res Ther. 2022 Dec 22;14(1):192. doi: 10.1186/s13195-022-01142-0. Alzheimers Res Ther. 2022. PMID: 36544221 Free PMC article.
In vivo quantification of neurofibrillary tangles with [18F]MK-6240.
Pascoal TA, Shin M, Kang MS, Chamoun M, Chartrand D, Mathotaarachchi S, Bennacef I, Therriault J, Ng KP, Hopewell R, Bouhachi R, Hsiao HH, Benedet AL, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: hopewell r. Alzheimers Res Ther. 2018 Jul 31;10(1):74. doi: 10.1186/s13195-018-0402-y. Alzheimers Res Ther. 2018. PMID: 30064520 Free PMC article.
[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.
Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P. Pascoal TA, et al. Among authors: hopewell r. Nat Commun. 2022 Jul 19;13(1):4171. doi: 10.1038/s41467-022-30653-5. Nat Commun. 2022. PMID: 35853847 Free PMC article.
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240.
Kunach P, Vaquer-Alicea J, Smith MS, Hopewell R, Monistrol J, Moquin L, Therriault J, Tissot C, Rahmouni N, Massarweh G, Soucy JP, Guiot MC, Shoichet BK, Rosa-Neto P, Diamond MI, Shahmoradian SH. Kunach P, et al. Among authors: hopewell r. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.558671. doi: 10.1101/2023.09.22.558671. bioRxiv. 2023. Update in: Nat Commun. 2024 Oct 1;15(1):8497. doi: 10.1038/s41467-024-52265-x PMID: 37790438 Free PMC article. Updated. Preprint.
Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue.
Aliaga A, Therriault J, Quispialaya KM, Aliaga A, Hopewell R, Rahmouni N, Macedo AC, Kunach P, Soucy JP, Massarweh G, Diaz AA, Pascoal TA, Rocha A, Guiot MC, Machado LS, De Bastiani MA, de Souza DG, Souza DO, Gauthier S, Zimmer ER, Rosa-Neto P. Aliaga A, et al. Among authors: hopewell r. J Nucl Med. 2024 Oct 30:jnumed.124.267539. doi: 10.2967/jnumed.124.267539. Online ahead of print. J Nucl Med. 2024. PMID: 39477493
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240.
Kunach P, Vaquer-Alicea J, Smith MS, Monistrol J, Hopewell R, Moquin L, Therriault J, Tissot C, Rahmouni N, Massarweh G, Soucy JP, Guiot MC, Shoichet BK, Rosa-Neto P, Diamond MI, Shahmoradian SH. Kunach P, et al. Among authors: hopewell r. Nat Commun. 2024 Oct 1;15(1):8497. doi: 10.1038/s41467-024-52265-x. Nat Commun. 2024. PMID: 39353896 Free PMC article.
A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging.
Hopewell R, Ross K, Kostikov A, Pascoal TA, Alberti T, Lacatus-Samoila M, Soucy JP, Bennacef I, Kobayashi E, Kang MS, Rosa-Neto P, Massarweh G. Hopewell R, et al. J Labelled Comp Radiopharm. 2019 Feb;62(2):109-114. doi: 10.1002/jlcr.3695. Epub 2018 Dec 19. J Labelled Comp Radiopharm. 2019. PMID: 30426529
48 results