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Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonist.
Haggag AZ, Xu J, Butcher L, Pagnussat S, Davies G, Lundqvist S, Wang W, Van Zuydam N, Nelander K, Jha A, Yu H, Boianelli A, Lindmark B, Ollerstam A, Sun X, Wang F, Pan X, Liu H, Chen W, Xu J, Wallenius K, Zhou J. Haggag AZ, et al. Among authors: zhou j. Diabetes Obes Metab. 2024 Nov 4. doi: 10.1111/dom.16047. Online ahead of print. Diabetes Obes Metab. 2024. PMID: 39495140
Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.
Liu LZ, Ma T, Zhou J, Long Hu Z, Jun Zhang X, Zhen Zhang H, Zeng M, Liu J, Li L, Jiang Y, Zou Z, Wang F, Zhang L, Xu J, Wang J, Xiao F, Fang X, Zou H, Efanov AM, Thomas MK, Lin HV, Chen J. Liu LZ, et al. Among authors: zhou j. Bioorg Med Chem Lett. 2020 Mar 1;30(5):126857. doi: 10.1016/j.bmcl.2019.126857. Epub 2019 Dec 27. Bioorg Med Chem Lett. 2020. PMID: 31982234
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