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TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms.
Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Bai J, Shahzad S, Nedumaran J, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier P, Ward M, Todd P, Barmada SJ. Dykstra MM, et al. Among authors: barmada sj. bioRxiv [Preprint]. 2024 Jul 4:2024.07.02.601776. doi: 10.1101/2024.07.02.601776. bioRxiv. 2024. PMID: 39005384 Free PMC article. Preprint.
AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS neurons.
Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Willey S, Van Deynze K, Mumm C, Boyle AP, Cortese A, Ndayisaba A, Khurana V, Barmada SJ, Dijkstra AA, Todd PK. Maltby CJ, et al. Among authors: barmada sj. Sci Adv. 2024 Sep 6;10(36):eadn2321. doi: 10.1126/sciadv.adn2321. Epub 2024 Sep 4. Sci Adv. 2024. PMID: 39231235 Free PMC article.
Molecular Visualization of Neuronal TDP43 Pathology In Situ.
Erwin AL, Chang ML, Fernandez MG, Attili D, Russ JE, Sutanto R, Pinarbasi ES, Bekier M, Brant TS, Hahn T, Dykstra M, Thomas D, Li X, Baldridge RD, Tank EMH, Barmada SJ, Mosalaganti S. Erwin AL, et al. Among authors: barmada sj. bioRxiv [Preprint]. 2024 Aug 19:2024.08.19.608477. doi: 10.1101/2024.08.19.608477. bioRxiv. 2024. PMID: 39229019 Free PMC article. Preprint.
Stress granule formation helps to mitigate neurodegeneration.
Glineburg MR, Yildirim E, Gomez N, Rodriguez G, Pak J, Li X, Altheim C, Waksmacki J, McInerney GM, Barmada SJ, Todd PK. Glineburg MR, et al. Among authors: barmada sj. Nucleic Acids Res. 2024 Sep 9;52(16):9745-9759. doi: 10.1093/nar/gkae655. Nucleic Acids Res. 2024. PMID: 39106168 Free PMC article.
Counter-regulation of RNA stability by UPF1 and TDP43.
Gomez N, Hsieh C, Li X, Dykstra M, Waksmacki J, Altheim C, Bechar Y, Klim J, Zaepfel B, Rothstein J, Tank EE, Barmada SJ. Gomez N, et al. Among authors: barmada sj. bioRxiv [Preprint]. 2024 Feb 15:2024.01.31.578310. doi: 10.1101/2024.01.31.578310. bioRxiv. 2024. PMID: 38352350 Free PMC article. Preprint.
AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons.
Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Khurana V, Barmada SJ, Dijkstra AA, Todd PK. Maltby CJ, et al. Among authors: barmada sj. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571345. doi: 10.1101/2023.12.13.571345. bioRxiv. 2023. Update in: Sci Adv. 2024 Sep 6;10(36):eadn2321. doi: 10.1126/sciadv.adn2321 PMID: 38168171 Free PMC article. Updated. Preprint.
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