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Page 1
Engineered extrachromosomal oncogene amplifications promote tumorigenesis.
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A. Pradella D, et al. Among authors: luebeck j. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8. Online ahead of print. Nature. 2024. PMID: 39695225
Enhancing transcription-replication conflict targets ecDNA-positive cancers.
Tang J, Weiser NE, Wang G, Chowdhry S, Curtis EJ, Zhao Y, Wong IT, Marinov GK, Li R, Hanoian P, Tse E, Mojica SG, Hansen R, Plum J, Steffy A, Milutinovic S, Meyer ST, Luebeck J, Wang Y, Zhang S, Altemose N, Curtis C, Greenleaf WJ, Bafna V, Benkovic SJ, Pinkerton AB, Kasibhatla S, Hassig CA, Mischel PS, Chang HY. Tang J, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):210-218. doi: 10.1038/s41586-024-07802-5. Epub 2024 Nov 6. Nature. 2024. PMID: 39506153 Free PMC article.
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung KL, Jones MG, Wong IT, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, Huang W, Cravatt BF, Henssen AG, Mischel PS, Chang HY. Hung KL, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):201-209. doi: 10.1038/s41586-024-07861-8. Epub 2024 Nov 6. Nature. 2024. PMID: 39506152 Free PMC article.
Origins and impact of extrachromosomal DNA.
Bailey C, Pich O, Thol K, Watkins TBK, Luebeck J, Rowan A, Stavrou G, Weiser NE, Dameracharla B, Bentham R, Lu WT, Kittel J, Yang SYC, Howitt BE, Sharma N, Litovchenko M, Salgado R, Hung KL, Cornish AJ, Moore DA, Houlston RS, Bafna V, Chang HY, Nik-Zainal S, Kanu N, McGranahan N; Genomics England Consortium; Flanagan AM, Mischel PS, Jamal-Hanjani M, Swanton C. Bailey C, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):193-200. doi: 10.1038/s41586-024-08107-3. Epub 2024 Nov 6. Nature. 2024. PMID: 39506150 Free PMC article.
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma.
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT, Kittel J, Bailey C, Weeden C, Bell D, Joo E, Barbe V, Jones MG, Nye E, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Nicoll J, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B. Noorani I, et al. Among authors: luebeck j. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.619657. doi: 10.1101/2024.10.22.619657. bioRxiv. 2024. PMID: 39484416 Free PMC article. Preprint.
Mapping extrachromosomal DNA amplifications during cancer progression.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson KC, An S, Ko J, Nam Y, Lee HY, Kang S, Chung H, Niclou SP, Moon HE, Paek SH, Bafna V, Luebeck J, Verhaak RGW. Kim H, et al. Among authors: luebeck j. Nat Genet. 2024 Nov;56(11):2447-2454. doi: 10.1038/s41588-024-01949-7. Epub 2024 Oct 14. Nat Genet. 2024. PMID: 39402156 Free PMC article.
Enhancer activation from transposable elements in extrachromosomal DNA.
Kraft K, Murphy SE, Jones MG, Shi Q, Bhargava-Shah A, Luong C, Hung KL, He BJ, Li R, Park SK, Weiser NE, Luebeck J, Bafna V, Boeke JD, Mischel PS, Boettiger AN, Chang HY. Kraft K, et al. Among authors: luebeck j. bioRxiv [Preprint]. 2024 Sep 8:2024.09.04.611262. doi: 10.1101/2024.09.04.611262. bioRxiv. 2024. PMID: 39282372 Free PMC article. Preprint.
Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer.
Nakagawa T, Luebeck J, Zhu K, Lange JT, Sasik R, Phillips C, Sadat S, Javadzadeh S, Yang Q, Wang A, Pestonjamasp K, Rosenthal B, Fisch KM, Mischel P, Bafna V, Califano JA. Nakagawa T, et al. Among authors: luebeck j. Res Sq [Preprint]. 2024 Sep 5:rs.3.rs-4636308. doi: 10.21203/rs.3.rs-4636308/v1. Res Sq. 2024. PMID: 39281879 Free PMC article. Preprint.
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair.
Rose JC, Belk JA, Wong IT, Luebeck J, Horn HT, Daniel B, Jones MG, Yost KE, Hung KL, Kolahi KS, Curtis EJ, Kuo CJ, Bafna V, Mischel PS, Chang HY. Rose JC, et al. Among authors: luebeck j. Cancer Discov. 2024 Aug 7. doi: 10.1158/2159-8290.CD-23-1117. Online ahead of print. Cancer Discov. 2024. PMID: 39109936
38 results