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Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death.
Virard F, Giraud S, Bonnet M, Magadoux L, Martin L, Pham TH, Skafi N, Deneuve S, Frem R, Villoutreix BO, Sleiman NH, Reboulet J, Merabet S, Chaptal V, Chaveroux C, Hussein N, Aznar N, Fenouil T, Treilleux I, Saintigny P, Ansieau S, Manié S, Lebecque S, Renno T, Coste I. Virard F, et al. Among authors: villoutreix bo. Nat Commun. 2024 Aug 15;15(1):7037. doi: 10.1038/s41467-024-51275-z. Nat Commun. 2024. PMID: 39147750 Free PMC article.
Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Picon S, Boulahjar R, Hoguet V, Baron M, Duplan I, Vallez E, Hennuyer N, Dumont J, Touche V, Dorchies E, Lasalle M, Descat A, Piveteau C, Biela A, Chaput L, Villoutreix BO, Lipka E, Sevin E, Culot M, Gosselet F, Lestavel S, Roussel P, Deprez-Poulain R, Leroux F, Staels B, Deprez B, Tailleux A, Charton J. Picon S, et al. Among authors: villoutreix bo. J Med Chem. 2023 Sep 14;66(17):11732-11760. doi: 10.1021/acs.jmedchem.2c01881. Epub 2023 Aug 28. J Med Chem. 2023. PMID: 37639383
Biallelic variants in NOS3 and GUCY1A3, the two major genes of the nitric oxide pathway, cause moyamoya cerebral angiopathy.
Guey S, Hervé D, Kossorotoff M, Ha G, Aloui C, Bergametti F, Arnould M, Guenou H, Hadjadj J, Dubois Teklali F, Riant F, Balligand JL, Uzan G, Villoutreix BO, Tournier-Lasserve E. Guey S, et al. Among authors: villoutreix bo. Hum Genomics. 2023 Mar 20;17(1):24. doi: 10.1186/s40246-023-00471-x. Hum Genomics. 2023. PMID: 36941667 Free PMC article.
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets.
Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC, Blom AM. Golec E, et al. Among authors: villoutreix bo. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2120083119. doi: 10.1073/pnas.2120083119. Epub 2022 Jun 6. Proc Natl Acad Sci U S A. 2022. PMID: 35666870 Free PMC article.
209 results