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Page 1
Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas.
Chen J, Sobecki M, Krzywinska E, Thierry K, Masmoudi M, Nagarajan S, Fan Z, He J, Ferapontova I, Nelius E, Seehusen F, Gotthardt D, Takeda N, Sommer L, Sexl V, Münz C, DeNardo D, Hennino A, Stockmann C. Chen J, et al. Among authors: gotthardt d. EMBO Mol Med. 2024 Dec;16(12):3033-3056. doi: 10.1038/s44321-024-00157-4. Epub 2024 Oct 30. EMBO Mol Med. 2024. PMID: 39478152 Free PMC article.
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance.
Putz EM, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, Straka E, Rigler D, Wallner B, Jamieson AM, Pickl WF, Zebedin-Brandl EM, Müller M, Decker T, Sexl V. Putz EM, et al. Among authors: gotthardt d. Cell Rep. 2013 Aug 15;4(3):437-44. doi: 10.1016/j.celrep.2013.07.012. Epub 2013 Aug 8. Cell Rep. 2013. PMID: 23933255 Free PMC article.
STAT1-S727 - the license to kill.
Putz EM, Gotthardt D, Sexl V. Putz EM, et al. Among authors: gotthardt d. Oncoimmunology. 2014 Dec 13;3(9):e955441. doi: 10.4161/21624011.2014.955441. eCollection 2014 Oct. Oncoimmunology. 2014. PMID: 25941617 Free PMC article.
In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.
Prchal-Murphy M, Witalisz-Siepracka A, Bednarik KT, Putz EM, Gotthardt D, Meissl K, Sexl V, Müller M, Strobl B. Prchal-Murphy M, et al. Among authors: gotthardt d. Oncoimmunology. 2015 May 26;4(11):e1047579. doi: 10.1080/2162402X.2015.1047579. eCollection 2015 Nov. Oncoimmunology. 2015. PMID: 26451322 Free PMC article.
STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion.
Gotthardt D, Putz EM, Grundschober E, Prchal-Murphy M, Straka E, Kudweis P, Heller G, Bago-Horvath Z, Witalisz-Siepracka A, Cumaraswamy AA, Gunning PT, Strobl B, Müller M, Moriggl R, Stockmann C, Sexl V. Gotthardt D, et al. Cancer Discov. 2016 Apr;6(4):414-29. doi: 10.1158/2159-8290.CD-15-0732. Epub 2016 Feb 12. Cancer Discov. 2016. PMID: 26873347
STATs in NK-Cells: The Good, the Bad, and the Ugly.
Gotthardt D, Sexl V. Gotthardt D, et al. Front Immunol. 2017 Jan 18;7:694. doi: 10.3389/fimmu.2016.00694. eCollection 2016. Front Immunol. 2017. PMID: 28149296 Free PMC article. Review.
195 results