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Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches.
Campos DL, Canales CSC, Demarqui FM, Fernandes GFS, Dos Santos CG, Prates JLB, da Silva IGM, Barros-Cordeiro KB, Báo SN, de Andrade LN, Abichabki N, Zacharias LV, de Campos MMA, Dos Santos JL, Pavan FR. Campos DL, et al. Among authors: dos santos jl. Front Microbiol. 2024 Oct 11;15:1487829. doi: 10.3389/fmicb.2024.1487829. eCollection 2024. Front Microbiol. 2024. PMID: 39464394 Free PMC article.
Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.
Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP, Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS, de Souza Costa CA, Cho SH, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL. Dos Santos Fernandes GF, et al. Among authors: dos santos jl. J Med Chem. 2017 Oct 26;60(20):8647-8660. doi: 10.1021/acs.jmedchem.7b01332. Epub 2017 Oct 16. J Med Chem. 2017. PMID: 28968083 Free PMC article.
Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection.
de Souza PC, Fernandes GFS, Marino LB, Ribeiro CM, Silva PBD, Chorilli M, Silva CSP, Resende FA, Solcia MC, de Grandis RA, Costa CAS, Cho SH, Wang Y, Franzblau SG, Dos Santos JL, Pavan FR. de Souza PC, et al. Among authors: dos santos jl. Biomed Pharmacother. 2020 Oct;130:110592. doi: 10.1016/j.biopha.2020.110592. Epub 2020 Aug 4. Biomed Pharmacother. 2020. PMID: 32763822 Free article.
Tuberculosis Drug Discovery: Challenges and New Horizons.
Fernandes GFS, Thompson AM, Castagnolo D, Denny WA, Dos Santos JL. Fernandes GFS, et al. Among authors: dos santos jl. J Med Chem. 2022 Jun 9;65(11):7489-7531. doi: 10.1021/acs.jmedchem.2c00227. Epub 2022 May 25. J Med Chem. 2022. PMID: 35612311 Review.
Synthesis and Anti-Mycobacterium tuberculosis Activity of Imidazo[2,1-b][1,3]oxazine Derivatives against Multidrug-Resistant Strains.
Fernandes GFS, Manieri KF, Bonjorno AF, Campos DL, Ribeiro CM, Demarqui FM, Ruiz DAG, Nascimento-Junior NM, Denny WA, Thompson AM, Pavan FR, Dos Santos JL. Fernandes GFS, et al. Among authors: dos santos jl. ChemMedChem. 2023 Jun 15;18(12):e202300015. doi: 10.1002/cmdc.202300015. Epub 2023 Apr 21. ChemMedChem. 2023. PMID: 37002895
194 results