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Page 1
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification.
Haag SM, Xie S, Eidenschenk C, Fortin JP, Callow M, Costa M, Lun A, Cox C, Wu SZ, Pradhan RN, Lock J, Kuhn JA, Holokai L, Thai M, Freund E, Nissenbaum A, Keir M, Bohlen CJ, Martin S, Geiger-Schuller K, Hejase HA, Yaspan BL, Melo Carlos S, Turley SJ, Murthy A. Haag SM, et al. Among authors: freund e. Nat Genet. 2024 Nov;56(11):2493-2505. doi: 10.1038/s41588-024-01962-w. Epub 2024 Oct 23. Nat Genet. 2024. PMID: 39443811
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327
Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Among authors: freund ec. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24. Nature. 2020. PMID: 32971525
Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo.
Thrift WJ, Lounsbury NW, Broadwell Q, Heidersbach A, Freund E, Abdolazimi Y, Phung QT, Chen J, Capietto AH, Tong AJ, Rose CM, Blanchette C, Lill JR, Haley B, Delamarre L, Bourgon R, Liu K, Jhunjhunwala S. Thrift WJ, et al. Among authors: freund e. Nat Commun. 2024 Dec 30;15(1):10752. doi: 10.1038/s41467-024-54887-7. Nat Commun. 2024. PMID: 39737928 Free PMC article.
Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses.
Camperi J, Roper B, Freund E, Leylek R, Nissenbaum A, Galan C, Caothien R, Hu Z, Ko P, Lee A, Chatla K, Ayalew L, Yang F, Lippold S, Guilbaud A. Camperi J, et al. Among authors: freund e. Anal Chem. 2024 Nov 5;96(44):17789-17799. doi: 10.1021/acs.analchem.4c04162. Epub 2024 Oct 24. Anal Chem. 2024. PMID: 39445393
189 results