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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Caldwell N, Peet C, Miller P, Colon BL, Taylor MG, Cocco M, Dawson A, Lukac I, Teixeira JE, Robinson L, Frame L, Seizova S, Damerow S, Tamaki F, Post J, Riley J, Mutter N, Hanna JC, Ferguson L, Hu X, Tinti M, Forte B, Norcross NR, Campbell PS, Svensen N, Caldwell FC, Jansen C, Postis V, Read KD, Huston CD, Gilbert IH, Baragaña B, Pawlowic MC. Caldwell N, et al. Among authors: pawlowic mc. Sci Transl Med. 2024 Oct 23;16(770):eadm8631. doi: 10.1126/scitranslmed.adm8631. Epub 2024 Oct 23. Sci Transl Med. 2024. PMID: 39441903
The first Cryptosporidium meeting: a concerted effort to fight cryptosporidiosis.
van Voorhis W, Siwila J, Kissinger JC, Vásquez NB, Robinson G, Baptista R, Khan A, Guérin A, Chang YW, Noor Z, Marzook NB, Vinayak S, Arnold S, Marie C, Choy RKM, Pawlowic MC, Jumani RS. van Voorhis W, et al. Among authors: pawlowic mc. Trends Parasitol. 2024 Jun;40(6):431-438. doi: 10.1016/j.pt.2024.04.005. Epub 2024 May 2. Trends Parasitol. 2024. PMID: 38702267 No abstract available.
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium.
Hanna JC, Corpas-Lopez V, Seizova S, Colon BL, Bacchetti R, Hall GMJ, Sands EM, Robinson L, Baragaña B, Wyllie S, Pawlowic MC. Hanna JC, et al. Among authors: pawlowic mc. Front Cell Infect Microbiol. 2023 Aug 4;13:1236814. doi: 10.3389/fcimb.2023.1236814. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37600947 Free PMC article.
Editorial: Molecular Basis of Stage Conversion in Apicomplexan Parasites.
Gissot M, Pawlowic MC, Modrzynska KK, Francia ME. Gissot M, et al. Among authors: pawlowic mc. Front Cell Infect Microbiol. 2021 Apr 16;11:680184. doi: 10.3389/fcimb.2021.680184. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33937107 Free PMC article. No abstract available.
A One Health Approach to Tackle Cryptosporidiosis.
Innes EA, Chalmers RM, Wells B, Pawlowic MC. Innes EA, et al. Among authors: pawlowic mc. Trends Parasitol. 2020 Mar;36(3):290-303. doi: 10.1016/j.pt.2019.12.016. Epub 2020 Jan 23. Trends Parasitol. 2020. PMID: 31983609 Free PMC article. Review.
14 results