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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Caldwell N, Peet C, Miller P, Colon BL, Taylor MG, Cocco M, Dawson A, Lukac I, Teixeira JE, Robinson L, Frame L, Seizova S, Damerow S, Tamaki F, Post J, Riley J, Mutter N, Hanna JC, Ferguson L, Hu X, Tinti M, Forte B, Norcross NR, Campbell PS, Svensen N, Caldwell FC, Jansen C, Postis V, Read KD, Huston CD, Gilbert IH, Baragaña B, Pawlowic MC. Caldwell N, et al. Among authors: dawson a. Sci Transl Med. 2024 Oct 23;16(770):eadm8631. doi: 10.1126/scitranslmed.adm8631. Epub 2024 Oct 23. Sci Transl Med. 2024. PMID: 39441903
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK, Buchanan KI, Post J, Dowers K, Shepherd SM, Jansen C, Zuccotto F, Gilbert IH, Epemolu O, Riley J, Stojanovski L, Osuna-Cabello M, Pérez-Herrán E, Rebollo MJ, Guijarro López L, Casado Castro P, Camino I, Kim HC, Bean JM, Nahiyaan N, Rhee KY, Wang Q, Tan VY, Boshoff HIM, Converse PJ, Li SY, Chang YS, Fotouhi N, Upton AM, Nuermberger EL, Schnappinger D, Read KD, Encinas L, Bates RH, Wyatt PG, Cleghorn LAT. Green SR, et al. Among authors: dawson a. Nat Commun. 2022 Oct 11;13(1):5992. doi: 10.1038/s41467-022-33736-5. Nat Commun. 2022. PMID: 36220877 Free PMC article.
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
Milne R, Wiedemar N, Corpas-Lopez V, Moynihan E, Wall RJ, Dawson A, Robinson DA, Shepherd SM, Smith RJ, Hallyburton I, Post JM, Dowers K, Torrie LS, Gilbert IH, Baragaña B, Patterson S, Wyllie S. Milne R, et al. Among authors: dawson a. ACS Infect Dis. 2022 Sep 9;8(9):1962-1974. doi: 10.1021/acsinfecdis.2c00364. Epub 2022 Aug 29. ACS Infect Dis. 2022. PMID: 36037410 Free PMC article.
Interactions between 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors.
Bueno RV, Davis S, Dawson A, Ondachi PW, Carroll FI, Hunter WN. Bueno RV, et al. Among authors: dawson a. Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):353-362. doi: 10.1107/S2059798322000754. Epub 2022 Feb 21. Acta Crystallogr D Struct Biol. 2022. PMID: 35234149 Free PMC article.
2,052 results