Campbell SG - Search Results

1

Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants.

Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Halder SS, et al. Among authors: campbell sg. J Clin Invest. 2024 Dec 16;134(24):e179135. doi: 10.1172/JCI179135. J Clin Invest. 2024. PMID: 39436707 Free PMC article.

2

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L.

Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Halder SS, et al. Among authors: campbell sg. PNAS Nexus. 2023 Jan 21;2(3):pgad011. doi: 10.1093/pnasnexus/pgad011. eCollection 2023 Mar. PNAS Nexus. 2023. PMID: 36896133 Free PMC article.

3

Structural determinants of muscle thin filament cooperativity.

Moore JR, Campbell SG, Lehman W. Moore JR, et al. Among authors: campbell sg. Arch Biochem Biophys. 2016 Mar 15;594:8-17. doi: 10.1016/j.abb.2016.02.016. Epub 2016 Feb 15. Arch Biochem Biophys. 2016. PMID: 26891592 Free PMC article. Review.

4

Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling.

Sewanan LR, Moore JR, Lehman W, Campbell SG. Sewanan LR, et al. Among authors: campbell sg. Front Physiol. 2016 Oct 26;7:473. doi: 10.3389/fphys.2016.00473. eCollection 2016. Front Physiol. 2016. PMID: 27833562 Free PMC article.

5

Modelling sarcomeric cardiomyopathies with human cardiomyocytes derived from induced pluripotent stem cells.

Sewanan LR, Campbell SG. Sewanan LR, et al. Among authors: campbell sg. J Physiol. 2020 Jul;598(14):2909-2922. doi: 10.1113/JP276753. Epub 2019 Feb 6. J Physiol. 2020. PMID: 30624779 Free PMC article. Review.

6

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. Lehman W, et al. Among authors: campbell sg. Biophys J. 2019 Jun 18;116(12):2275-2284. doi: 10.1016/j.bpj.2019.05.009. Epub 2019 May 13. Biophys J. 2019. PMID: 31130236 Free PMC article.

7

Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue.

Sewanan LR, Shen S, Campbell SG. Sewanan LR, et al. Among authors: campbell sg. Am J Physiol Heart Circ Physiol. 2021 Mar 1;320(3):H1112-H1123. doi: 10.1152/ajpheart.00325.2020. Epub 2021 Jan 15. Am J Physiol Heart Circ Physiol. 2021. PMID: 33449850 Free PMC article.

8

Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling.

Shen S, Sewanan LR, Campbell SG. Shen S, et al. Among authors: campbell sg. J Mol Cell Cardiol. 2021 Sep;158:11-25. doi: 10.1016/j.yjmcc.2021.05.005. Epub 2021 May 14. J Mol Cell Cardiol. 2021. PMID: 33992697 Free PMC article.

9

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.

Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Sewanan LR, et al. Among authors: campbell sg. J Gen Physiol. 2021 Sep 6;153(9):e202012640. doi: 10.1085/jgp.202012640. Epub 2021 Jul 28. J Gen Physiol. 2021. PMID: 34319370 Free PMC article.

10

In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R.

Creso JG, Gokhan I, Rynkiewicz MJ, Lehman W, Moore JR, Campbell SG. Creso JG, et al. Among authors: campbell sg. Front Physiol. 2024 Aug 30;15:1452509. doi: 10.3389/fphys.2024.1452509. eCollection 2024. Front Physiol. 2024. PMID: 39282088 Free PMC article.

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