Schofield CJ - Search Results

1

Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease.

Wu Y, Zhang Z, Cai H, Zhang W, Zhang L, Li Z, Yang L, Chen Y, Corner TP, Song Z, Yue J, Yang F, Li X, Schofield CJ, Zhang X. Wu Y, et al. Among authors: schofield cj. J Med Chem. 2024 Oct 21. doi: 10.1021/acs.jmedchem.4c01698. Online ahead of print. J Med Chem. 2024. PMID: 39432709

2

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

Schofield CJ, Zhang Z. Schofield CJ, et al. Curr Opin Struct Biol. 1999 Dec;9(6):722-31. doi: 10.1016/s0959-440x(99)00036-6. Curr Opin Struct Biol. 1999. PMID: 10607676 Review.

3

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Hewitson KS, et al. Among authors: schofield cj. J Biol Chem. 2008 Sep 19;283(38):25971-8. doi: 10.1074/jbc.M804999200. Epub 2008 Jul 8. J Biol Chem. 2008. PMID: 18611856 Free PMC article.

4

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

5

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. Mecinović J, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. doi: 10.1016/j.bmcl.2009.09.005. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19775891

6

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.

Leung IK, Flashman E, Yeoh KK, Schofield CJ, Claridge TD. Leung IK, et al. Among authors: schofield cj. J Med Chem. 2010 Jan 28;53(2):867-75. doi: 10.1021/jm901537q. J Med Chem. 2010. PMID: 20025281

7

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2010 Feb 25;53(4):1810-8. doi: 10.1021/jm901680b. J Med Chem. 2010. PMID: 20088513 Free PMC article.

8

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Conejo-Garcia A, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. doi: 10.1016/j.bmcl.2010.08.032. Epub 2010 Aug 10. Bioorg Med Chem Lett. 2010. PMID: 20822901

9

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Woon EC, et al. Among authors: schofield cj. J Med Chem. 2012 Mar 8;55(5):2173-84. doi: 10.1021/jm201417e. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22263962

10

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Leung IK, et al. Among authors: schofield cj. J Med Chem. 2013 Jan 24;56(2):547-55. doi: 10.1021/jm301583m. Epub 2013 Jan 4. J Med Chem. 2013. PMID: 23234607 Free PMC article.

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