Li Z - Search Results

1

Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease.

Wu Y, Zhang Z, Cai H, Zhang W, Zhang L, Li Z, Yang L, Chen Y, Corner TP, Song Z, Yue J, Yang F, Li X, Schofield CJ, Zhang X. Wu Y, et al. Among authors: li z, li x. J Med Chem. 2024 Oct 21. doi: 10.1021/acs.jmedchem.4c01698. Online ahead of print. J Med Chem. 2024. PMID: 39432709

2

Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.

Wu Y, Jiang Z, Li Z, Gu J, You Q, Zhang X. Wu Y, et al. Among authors: li z. J Med Chem. 2018 Jun 28;61(12):5332-5349. doi: 10.1021/acs.jmedchem.8b00549. Epub 2018 Jun 12. J Med Chem. 2018. PMID: 29856623

3

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.

Zhang X, Lei Y, Hu T, Wu Y, Li Z, Jiang Z, Yang C, Zhang L, You Q. Zhang X, et al. Among authors: li z. J Med Chem. 2020 Sep 10;63(17):10045-10060. doi: 10.1021/acs.jmedchem.0c01161. Epub 2020 Aug 5. J Med Chem. 2020. PMID: 32787144

4

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.

Wu Y, Li Z, McDonough MA, Schofield CJ, Zhang X. Wu Y, et al. Among authors: li z. J Med Chem. 2021 Jun 10;64(11):7189-7209. doi: 10.1021/acs.jmedchem.1c00415. Epub 2021 May 24. J Med Chem. 2021. PMID: 34029087 Review.

5

Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia.

Yu Y, Yang F, Yu Q, Liu S, Wu C, Su K, Yang L, Bao X, Li Z, Li X, Zhang X. Yu Y, et al. Among authors: li z, li x. J Med Chem. 2021 Dec 9;64(23):17384-17402. doi: 10.1021/acs.jmedchem.1c01479. Epub 2021 Oct 28. J Med Chem. 2021. PMID: 34709043

6

A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity.

Wu Y, Chen Y, Corner TP, Nakashima Y, Salah E, Li Z, Zhang L, Yang L, Tumber A, Sun Z, Wen Y, Zhong A, Yang F, Li X, Zhang Z, Schofield CJ, Zhang X. Wu Y, et al. Among authors: li z, li x. Angew Chem Int Ed Engl. 2024 Oct 1;63(40):e202410438. doi: 10.1002/anie.202410438. Epub 2024 Jul 31. Angew Chem Int Ed Engl. 2024. PMID: 38923188

7

Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.

Wu X, Li X, Li Z, Yu Y, You Q, Zhang X. Wu X, et al. Among authors: li z, li x. J Med Chem. 2018 Dec 27;61(24):11280-11297. doi: 10.1021/acs.jmedchem.8b01424. Epub 2018 Dec 10. J Med Chem. 2018. PMID: 30508483

8

Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.

Li Z, You Q, Zhang X. Li Z, et al. J Med Chem. 2019 Jun 27;62(12):5725-5749. doi: 10.1021/acs.jmedchem.8b01596. Epub 2019 Feb 8. J Med Chem. 2019. PMID: 30682255 Review.

9

Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light.

Li Z, Su K, Jiang Z, Yu Y, You Q, Zhang X. Li Z, et al. J Med Chem. 2019 Aug 22;62(16):7583-7588. doi: 10.1021/acs.jmedchem.9b00688. Epub 2019 Jun 25. J Med Chem. 2019. PMID: 31244107

10

Tetrahydropyridin-4-ylpicolinoylglycines as novel and orally active prolyl hydroxylase 2 (PHD2) inhibitors for the treatment of renal anemia.

Su K, Li Z, Zhang L, Fang S, Mao M, Sun Z, Zhang X. Su K, et al. Among authors: li z. Eur J Med Chem. 2022 Aug 5;238:114479. doi: 10.1016/j.ejmech.2022.114479. Epub 2022 May 25. Eur J Med Chem. 2022. PMID: 35675755

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

112,920 results

Search Page

Filters