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Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction.
Huang KC, Gomes C, Shiga Y, Belforte N, VanderWall KB, Lavekar SS, Fligor CM, Harkin J, Hetzer SM, Patil SV, Di Polo A, Meyer JS. Huang KC, et al. Acta Neuropathol Commun. 2024 Oct 18;12(1):164. doi: 10.1186/s40478-024-01872-2. Acta Neuropathol Commun. 2024. PMID: 39425218 Free PMC article.
Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.
VanderWall KB, Huang KC, Pan Y, Lavekar SS, Fligor CM, Allsop AR, Lentsch KA, Dang P, Zhang C, Tseng HC, Cummins TR, Meyer JS. VanderWall KB, et al. Among authors: huang kc. Stem Cell Reports. 2020 Jul 14;15(1):52-66. doi: 10.1016/j.stemcr.2020.05.009. Epub 2020 Jun 11. Stem Cell Reports. 2020. PMID: 32531194 Free PMC article.
Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma.
Huang KC, Gomes C, Shiga Y, Belforte N, VanderWall KB, Lavekar SS, Fligor CM, Harkin J, Di Polo A, Meyer JS. Huang KC, et al. bioRxiv [Preprint]. 2023 Jan 4:2023.01.04.522687. doi: 10.1101/2023.01.04.522687. bioRxiv. 2023. Update in: Acta Neuropathol Commun. 2024 Oct 18;12(1):164. doi: 10.1186/s40478-024-01872-2 PMID: 36711831 Free PMC article. Updated. Preprint.
Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.
Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J; RReSTORe Consortium; Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. Soucy JR, et al. Mol Neurodegener. 2023 Sep 21;18(1):64. doi: 10.1186/s13024-023-00655-y. Mol Neurodegener. 2023. PMID: 37735444 Free PMC article. Review.
1,054 results